Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var gene family, causing parasites with different...

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Autores principales:	Mario Recker, Caroline O Buckee, Andrew Serazin, Sue Kyes, Robert Pinches, Zóe Christodoulou, Amy L Springer, Sunetra Gupta, Chris I Newbold
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/69c4427ffae3482883a2ac9c357f4a22
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spelling	oai:doaj.org-article:69c4427ffae3482883a2ac9c357f4a222021-11-18T06:03:33ZAntigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.1553-73661553-737410.1371/journal.ppat.1001306https://doaj.org/article/69c4427ffae3482883a2ac9c357f4a222011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408201/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var gene family, causing parasites with different antigenic and phenotypic characteristics to appear at different times within a population. Here we use a genome-wide approach to explore this process in vitro within a set of cloned parasite populations. Our analyses reveal a non-random, highly structured switch pathway where an initially dominant transcript switches via a set of switch-intermediates either to a new dominant transcript, or back to the original. We show that this specific pathway can arise through an evolutionary conflict in which the pathogen has to optimise between safeguarding its limited antigenic repertoire and remaining capable of establishing infections in non-naïve individuals. Our results thus demonstrate a crucial role for structured switching during the early phases of infections and provide a unifying theory of antigenic variation in P. falciparum malaria as a balanced process of parasite-intrinsic switching and immune-mediated selection.Mario ReckerCaroline O BuckeeAndrew SerazinSue KyesRobert PinchesZóe ChristodoulouAmy L SpringerSunetra GuptaChris I NewboldPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 3, p e1001306 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Mario Recker Caroline O Buckee Andrew Serazin Sue Kyes Robert Pinches Zóe Christodoulou Amy L Springer Sunetra Gupta Chris I Newbold Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
description	Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var gene family, causing parasites with different antigenic and phenotypic characteristics to appear at different times within a population. Here we use a genome-wide approach to explore this process in vitro within a set of cloned parasite populations. Our analyses reveal a non-random, highly structured switch pathway where an initially dominant transcript switches via a set of switch-intermediates either to a new dominant transcript, or back to the original. We show that this specific pathway can arise through an evolutionary conflict in which the pathogen has to optimise between safeguarding its limited antigenic repertoire and remaining capable of establishing infections in non-naïve individuals. Our results thus demonstrate a crucial role for structured switching during the early phases of infections and provide a unifying theory of antigenic variation in P. falciparum malaria as a balanced process of parasite-intrinsic switching and immune-mediated selection.
format	article
author	Mario Recker Caroline O Buckee Andrew Serazin Sue Kyes Robert Pinches Zóe Christodoulou Amy L Springer Sunetra Gupta Chris I Newbold
author_facet	Mario Recker Caroline O Buckee Andrew Serazin Sue Kyes Robert Pinches Zóe Christodoulou Amy L Springer Sunetra Gupta Chris I Newbold
author_sort	Mario Recker
title	Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
title_short	Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
title_full	Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
title_fullStr	Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
title_full_unstemmed	Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.
title_sort	antigenic variation in plasmodium falciparum malaria involves a highly structured switching pattern.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/69c4427ffae3482883a2ac9c357f4a22
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Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

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