Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors

Abstract We examined cross-sectional associations between arm lymphedema symptoms and health-related quality of life (HRQoL) in the Health, Eating, Activity and Lifestyle (HEAL) Study. 499 women diagnosed with localized or regional breast cancer at ages 35–64 years completed a survey, on average 40 ...

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Autores principales:	Kayo Togawa, Huiyan Ma, Ashley Wilder Smith, Marian L. Neuhouser, Stephanie M. George, Kathy B. Baumgartner, Anne McTiernan, Richard Baumgartner, Rachel M. Ballard, Leslie Bernstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69c61396eb054b2b8ee520d768b1963c
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spelling	oai:doaj.org-article:69c61396eb054b2b8ee520d768b1963c2021-12-02T14:59:12ZSelf-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors10.1038/s41598-021-89055-02045-2322https://doaj.org/article/69c61396eb054b2b8ee520d768b1963c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89055-0https://doaj.org/toc/2045-2322Abstract We examined cross-sectional associations between arm lymphedema symptoms and health-related quality of life (HRQoL) in the Health, Eating, Activity and Lifestyle (HEAL) Study. 499 women diagnosed with localized or regional breast cancer at ages 35–64 years completed a survey, on average 40 months after diagnosis, querying presence of lymphedema, nine lymphedema-related symptoms, e.g., tension, burning pain, mobility loss, and warmth/redness, and HRQoL. Analysis of covariance models were used to assess HRQoL scores in relation to presence of lymphedema and lymphedema-related symptoms. Lymphedema was self-reported by 137 women, of whom 98 were experiencing lymphedema at the time of the assessment. The most common symptoms were heaviness (52%), numbness (47%), and tightness (45%). Perceived physical health was worse for women reporting past or current lymphedema than those reporting no lymphedema (P-value < 0.0001). No difference was observed for perceived mental health (P-value = 0.31). Perceived physical health, stress, and lymphedema-specific HRQoL scores worsened as number of symptoms increased (P-values ≤ 0.01). Women reporting tension in the arm had lower physical health (P-value = 0.01), and those experiencing burning pain, tension, heaviness, or warmth/redness in the arm had lower lymphedema-specific HRQoL (P-values < 0.05). Treatment targeting specific lymphedema-related symptoms in addition to size/volume reduction may improve some aspects of HRQoL among affected women.Kayo TogawaHuiyan MaAshley Wilder SmithMarian L. NeuhouserStephanie M. GeorgeKathy B. BaumgartnerAnne McTiernanRichard BaumgartnerRachel M. BallardLeslie BernsteinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kayo Togawa Huiyan Ma Ashley Wilder Smith Marian L. Neuhouser Stephanie M. George Kathy B. Baumgartner Anne McTiernan Richard Baumgartner Rachel M. Ballard Leslie Bernstein Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
description	Abstract We examined cross-sectional associations between arm lymphedema symptoms and health-related quality of life (HRQoL) in the Health, Eating, Activity and Lifestyle (HEAL) Study. 499 women diagnosed with localized or regional breast cancer at ages 35–64 years completed a survey, on average 40 months after diagnosis, querying presence of lymphedema, nine lymphedema-related symptoms, e.g., tension, burning pain, mobility loss, and warmth/redness, and HRQoL. Analysis of covariance models were used to assess HRQoL scores in relation to presence of lymphedema and lymphedema-related symptoms. Lymphedema was self-reported by 137 women, of whom 98 were experiencing lymphedema at the time of the assessment. The most common symptoms were heaviness (52%), numbness (47%), and tightness (45%). Perceived physical health was worse for women reporting past or current lymphedema than those reporting no lymphedema (P-value < 0.0001). No difference was observed for perceived mental health (P-value = 0.31). Perceived physical health, stress, and lymphedema-specific HRQoL scores worsened as number of symptoms increased (P-values ≤ 0.01). Women reporting tension in the arm had lower physical health (P-value = 0.01), and those experiencing burning pain, tension, heaviness, or warmth/redness in the arm had lower lymphedema-specific HRQoL (P-values < 0.05). Treatment targeting specific lymphedema-related symptoms in addition to size/volume reduction may improve some aspects of HRQoL among affected women.
format	article
author	Kayo Togawa Huiyan Ma Ashley Wilder Smith Marian L. Neuhouser Stephanie M. George Kathy B. Baumgartner Anne McTiernan Richard Baumgartner Rachel M. Ballard Leslie Bernstein
author_facet	Kayo Togawa Huiyan Ma Ashley Wilder Smith Marian L. Neuhouser Stephanie M. George Kathy B. Baumgartner Anne McTiernan Richard Baumgartner Rachel M. Ballard Leslie Bernstein
author_sort	Kayo Togawa
title	Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
title_short	Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
title_full	Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
title_fullStr	Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
title_full_unstemmed	Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
title_sort	self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69c61396eb054b2b8ee520d768b1963c
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Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors

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