COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

BACKGROUND AND OBJECTIVE: Clomiphene citrate is the first–line treatment in patients with ovulatory dysfunction, but it may be associated with side effects for example multiple follicles, multiple pregnancy and adverse effects on endometrial growth. Nowadays, it is considered to use letrozole for in...

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Autores principales:	M Zeinalzadeh, M Esmailpour, T Nazari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	infertility polycystic ovarian syndrome letrozole clomiphene citrate Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/69c780b1f8be47b9a042a2deb13e1892
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spelling	oai:doaj.org-article:69c780b1f8be47b9a042a2deb13e18922021-11-10T09:07:36ZCOMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME1561-41072251-7170https://doaj.org/article/69c780b1f8be47b9a042a2deb13e18922008-08-01T00:00:00Zhttp://jbums.org/article-1-2469-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Clomiphene citrate is the first–line treatment in patients with ovulatory dysfunction, but it may be associated with side effects for example multiple follicles, multiple pregnancy and adverse effects on endometrial growth. Nowadays, it is considered to use letrozole for induction ovulation. The aim of this study was to compare letrozole with clomiphene citrate for ovulation induction, in patients with polycystic ovarian syndrome (PCOs). METHODS: This clinical trial study was performed on 107 PCOs patients. They divided into two groups. Group one received 100mg clomiphene citrate (n=57) and group two received 5mg letrozole (n=50) daily on days 3-7 of their menstrual cycle. Human chorionic gonadotrplin (hCG) at a dose of 10000IU was administered when at least one mature follicle was observed. A single IUI was performed 34 hours later. Then size and number of mature follicles, ovulation rate, endometrial thickness and pregnancy rate was measured. FINDINGS: The number and the size of mature follicles were similar between two groups. The pregnancy rate in letrozole was 6% higher than clomiphene group (20% vs. 14%) that did not show significant difference. Endometrial thickness in letrozole and clomiphene citrate group was 64% and 64.9%, respectively. 86% of patients developed mature follicle in letrozole group who all of them showed ovulation, but in 72% of patients in clomiphene citrate group was developed mature follicles. CONCLUSION: Letrozole may be an acceptable alternative to clomiphene citrate for ovulation induction and pregnancy rate in PCOs patients.M Zeinalzadeh,M EsmailpourT NazariBabol University of Medical Sciencesarticleinfertilitypolycystic ovarian syndromeletrozoleclomiphene citrateMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 3, Pp 35-41 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	infertility polycystic ovarian syndrome letrozole clomiphene citrate Medicine R Medicine (General) R5-920
spellingShingle	infertility polycystic ovarian syndrome letrozole clomiphene citrate Medicine R Medicine (General) R5-920 M Zeinalzadeh, M Esmailpour T Nazari COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
description	BACKGROUND AND OBJECTIVE: Clomiphene citrate is the first–line treatment in patients with ovulatory dysfunction, but it may be associated with side effects for example multiple follicles, multiple pregnancy and adverse effects on endometrial growth. Nowadays, it is considered to use letrozole for induction ovulation. The aim of this study was to compare letrozole with clomiphene citrate for ovulation induction, in patients with polycystic ovarian syndrome (PCOs). METHODS: This clinical trial study was performed on 107 PCOs patients. They divided into two groups. Group one received 100mg clomiphene citrate (n=57) and group two received 5mg letrozole (n=50) daily on days 3-7 of their menstrual cycle. Human chorionic gonadotrplin (hCG) at a dose of 10000IU was administered when at least one mature follicle was observed. A single IUI was performed 34 hours later. Then size and number of mature follicles, ovulation rate, endometrial thickness and pregnancy rate was measured. FINDINGS: The number and the size of mature follicles were similar between two groups. The pregnancy rate in letrozole was 6% higher than clomiphene group (20% vs. 14%) that did not show significant difference. Endometrial thickness in letrozole and clomiphene citrate group was 64% and 64.9%, respectively. 86% of patients developed mature follicle in letrozole group who all of them showed ovulation, but in 72% of patients in clomiphene citrate group was developed mature follicles. CONCLUSION: Letrozole may be an acceptable alternative to clomiphene citrate for ovulation induction and pregnancy rate in PCOs patients.
format	article
author	M Zeinalzadeh, M Esmailpour T Nazari
author_facet	M Zeinalzadeh, M Esmailpour T Nazari
author_sort	M Zeinalzadeh,
title	COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
title_short	COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
title_full	COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
title_fullStr	COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
title_full_unstemmed	COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
title_sort	comparison of letrozole and clomiphene citrate for induction of ovulation in patients with polycystic ovarian syndrome
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/69c780b1f8be47b9a042a2deb13e1892
work_keys_str_mv	AT mzeinalzadeh comparisonofletrozoleandclomiphenecitrateforinductionofovulationinpatientswithpolycysticovariansyndrome AT mesmailpour comparisonofletrozoleandclomiphenecitrateforinductionofovulationinpatientswithpolycysticovariansyndrome AT tnazari comparisonofletrozoleandclomiphenecitrateforinductionofovulationinpatientswithpolycysticovariansyndrome
_version_	1718440293391400960

COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE FOR INDUCTION OF OVULATION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

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