Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants
Background: Oral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED and RVV immunogenicity, and evaluated the effect of...
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Elsevier
2021
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oai:doaj.org-article:69cb5ba48b6d461b9a9af23e66c7c2842021-11-18T04:51:16ZAssociations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants2589-537010.1016/j.eclinm.2021.101173https://doaj.org/article/69cb5ba48b6d461b9a9af23e66c7c2842021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589537021004533https://doaj.org/toc/2589-5370Background: Oral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED and RVV immunogenicity, and evaluated the effect of improved WASH on EED. Methods: We measured nine biomarkers of EED among Zimbabwean infants born to mothers enrolled in a cluster-randomised 2 × 2 factorial trial of improved WASH and improved feeding between November 2012 and March 2015 (NCT01824940). We used multivariable regression to determine associations between EED biomarkers and RVV seroconversion, seropositivity and geometric mean titer. Log-binomial regression was used to evaluate the effect of improved WASH on EED. Findings: Among 303 infants with EED biomarkers and immunogenicity data, plasma intestinal fatty-acid binding protein and stool myeloperoxidase were positively associated with RVV seroconversion; adjusted RR 1.63 (95%CI 1.04, 2.57) and 1.29 (95%CI 1.01, 1.65), respectively. There were no other associations between RVV immunogenicity and either individual biomarkers or EED domains (intestinal permeability, intestinal damage, intestinal inflammation and microbial translocation). EED biomarkers did not differ between randomised WASH and non-WASH groups. Interpretation: We found no evidence that EED was associated with poor RVV immunogenicity. Contrary to our hypothesis, there was weak evidence that EED was associated with increased seroconversion. EED biomarkers were not affected by a package of household-level WASH interventions.James A ChurchSandra RukoboMargaret GovhaEthan K GoughBernard ChasekwaBenjamin LeeMarya P CarmolliGordana PanicNatasa GiallourouRobert NtoziniKuda MutasaMonica M McNealFlorence D. MajoNaume V. TavengwaJonathan R. SwannLawrence H MoultonBeth D KirkpatrickJean H HumphreyAndrew J PrendergastElsevierarticleInfantsAfricaRotavirusOral vaccineEnteropathyEnvironmental enteric dysfunctionMedicine (General)R5-920ENEClinicalMedicine, Vol 41, Iss , Pp 101173- (2021) |
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DOAJ |
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EN |
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Infants Africa Rotavirus Oral vaccine Enteropathy Environmental enteric dysfunction Medicine (General) R5-920 |
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Infants Africa Rotavirus Oral vaccine Enteropathy Environmental enteric dysfunction Medicine (General) R5-920 James A Church Sandra Rukobo Margaret Govha Ethan K Gough Bernard Chasekwa Benjamin Lee Marya P Carmolli Gordana Panic Natasa Giallourou Robert Ntozini Kuda Mutasa Monica M McNeal Florence D. Majo Naume V. Tavengwa Jonathan R. Swann Lawrence H Moulton Beth D Kirkpatrick Jean H Humphrey Andrew J Prendergast Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| description |
Background: Oral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED and RVV immunogenicity, and evaluated the effect of improved WASH on EED. Methods: We measured nine biomarkers of EED among Zimbabwean infants born to mothers enrolled in a cluster-randomised 2 × 2 factorial trial of improved WASH and improved feeding between November 2012 and March 2015 (NCT01824940). We used multivariable regression to determine associations between EED biomarkers and RVV seroconversion, seropositivity and geometric mean titer. Log-binomial regression was used to evaluate the effect of improved WASH on EED. Findings: Among 303 infants with EED biomarkers and immunogenicity data, plasma intestinal fatty-acid binding protein and stool myeloperoxidase were positively associated with RVV seroconversion; adjusted RR 1.63 (95%CI 1.04, 2.57) and 1.29 (95%CI 1.01, 1.65), respectively. There were no other associations between RVV immunogenicity and either individual biomarkers or EED domains (intestinal permeability, intestinal damage, intestinal inflammation and microbial translocation). EED biomarkers did not differ between randomised WASH and non-WASH groups. Interpretation: We found no evidence that EED was associated with poor RVV immunogenicity. Contrary to our hypothesis, there was weak evidence that EED was associated with increased seroconversion. EED biomarkers were not affected by a package of household-level WASH interventions. |
| format |
article |
| author |
James A Church Sandra Rukobo Margaret Govha Ethan K Gough Bernard Chasekwa Benjamin Lee Marya P Carmolli Gordana Panic Natasa Giallourou Robert Ntozini Kuda Mutasa Monica M McNeal Florence D. Majo Naume V. Tavengwa Jonathan R. Swann Lawrence H Moulton Beth D Kirkpatrick Jean H Humphrey Andrew J Prendergast |
| author_facet |
James A Church Sandra Rukobo Margaret Govha Ethan K Gough Bernard Chasekwa Benjamin Lee Marya P Carmolli Gordana Panic Natasa Giallourou Robert Ntozini Kuda Mutasa Monica M McNeal Florence D. Majo Naume V. Tavengwa Jonathan R. Swann Lawrence H Moulton Beth D Kirkpatrick Jean H Humphrey Andrew J Prendergast |
| author_sort |
James A Church |
| title |
Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| title_short |
Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| title_full |
Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| title_fullStr |
Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| title_full_unstemmed |
Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants |
| title_sort |
associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural zimbabwean infants |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/69cb5ba48b6d461b9a9af23e66c7c284 |
| work_keys_str_mv |
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