Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability...

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Autores principales:	Brunilde Gril, Anurag N. Paranjape, Stephan Woditschka, Emily Hua, Emma L. Dolan, Jeffrey Hanson, Xiaolin Wu, Wojciech Kloc, Ewa Izycka-Swieszewska, Renata Duchnowska, Rafał Pęksa, Wojciech Biernat, Jacek Jassem, Naema Nayyar, Priscilla K. Brastianos, O. Morgan Hall, Cody J. Peer, William D. Figg, Gary T. Pauly, Christina Robinson, Simone Difilippantonio, Emilie Bialecki, Philippe Metellus, Joel P. Schneider, Patricia S. Steeg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69cb9612d00a46d3a48171a71ecd0d7b
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spelling	oai:doaj.org-article:69cb9612d00a46d3a48171a71ecd0d7b2021-12-02T17:32:16ZReactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases10.1038/s41467-018-05030-w2041-1723https://doaj.org/article/69cb9612d00a46d3a48171a71ecd0d7b2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05030-whttps://doaj.org/toc/2041-1723When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability.Brunilde GrilAnurag N. ParanjapeStephan WoditschkaEmily HuaEmma L. DolanJeffrey HansonXiaolin WuWojciech KlocEwa Izycka-SwieszewskaRenata DuchnowskaRafał PęksaWojciech BiernatJacek JassemNaema NayyarPriscilla K. BrastianosO. Morgan HallCody J. PeerWilliam D. FiggGary T. PaulyChristina RobinsonSimone DifilippantonioEmilie BialeckiPhilippe MetellusJoel P. SchneiderPatricia S. SteegNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brunilde Gril Anurag N. Paranjape Stephan Woditschka Emily Hua Emma L. Dolan Jeffrey Hanson Xiaolin Wu Wojciech Kloc Ewa Izycka-Swieszewska Renata Duchnowska Rafał Pęksa Wojciech Biernat Jacek Jassem Naema Nayyar Priscilla K. Brastianos O. Morgan Hall Cody J. Peer William D. Figg Gary T. Pauly Christina Robinson Simone Difilippantonio Emilie Bialecki Philippe Metellus Joel P. Schneider Patricia S. Steeg Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
description	When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability.
format	article
author	Brunilde Gril Anurag N. Paranjape Stephan Woditschka Emily Hua Emma L. Dolan Jeffrey Hanson Xiaolin Wu Wojciech Kloc Ewa Izycka-Swieszewska Renata Duchnowska Rafał Pęksa Wojciech Biernat Jacek Jassem Naema Nayyar Priscilla K. Brastianos O. Morgan Hall Cody J. Peer William D. Figg Gary T. Pauly Christina Robinson Simone Difilippantonio Emilie Bialecki Philippe Metellus Joel P. Schneider Patricia S. Steeg
author_facet	Brunilde Gril Anurag N. Paranjape Stephan Woditschka Emily Hua Emma L. Dolan Jeffrey Hanson Xiaolin Wu Wojciech Kloc Ewa Izycka-Swieszewska Renata Duchnowska Rafał Pęksa Wojciech Biernat Jacek Jassem Naema Nayyar Priscilla K. Brastianos O. Morgan Hall Cody J. Peer William D. Figg Gary T. Pauly Christina Robinson Simone Difilippantonio Emilie Bialecki Philippe Metellus Joel P. Schneider Patricia S. Steeg
author_sort	Brunilde Gril
title	Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
title_short	Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
title_full	Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
title_fullStr	Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
title_full_unstemmed	Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
title_sort	reactive astrocytic s1p3 signaling modulates the blood–tumor barrier in brain metastases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/69cb9612d00a46d3a48171a71ecd0d7b
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Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

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