Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study the effect of PARP inhibitors in cancer cells.

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Autores principales:	Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69cfbc985a4f4f299345fc43300b4c9c
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spelling	oai:doaj.org-article:69cfbc985a4f4f299345fc43300b4c9c2021-12-02T15:34:46ZAnalysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance10.1038/s41467-018-05031-92041-1723https://doaj.org/article/69cfbc985a4f4f299345fc43300b4c9c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05031-9https://doaj.org/toc/2041-1723Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study the effect of PARP inhibitors in cancer cells.Jone MichelenaAleksandra LezajaFederico TeloniThomas SchmidRalph ImhofMatthias AltmeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jone Michelena Aleksandra Lezaja Federico Teloni Thomas Schmid Ralph Imhof Matthias Altmeyer Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
description	Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study the effect of PARP inhibitors in cancer cells.
format	article
author	Jone Michelena Aleksandra Lezaja Federico Teloni Thomas Schmid Ralph Imhof Matthias Altmeyer
author_facet	Jone Michelena Aleksandra Lezaja Federico Teloni Thomas Schmid Ralph Imhof Matthias Altmeyer
author_sort	Jone Michelena
title	Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
title_short	Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
title_full	Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
title_fullStr	Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
title_full_unstemmed	Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
title_sort	analysis of parp inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/69cfbc985a4f4f299345fc43300b4c9c
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Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

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