Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma
Catherine Q Sun, Tiffany A Chen, Michael S Deiner, Yvonne Ou Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USACorrespondence: Catherine Q SunUCSF F.I. Proctor Foundation, 490 Illinois Street, Floor 2, San Francisco, CA 94143, USAEmail catherine.sun@ucsf.eduB...
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Dove Medical Press
2021
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oai:doaj.org-article:69d0152189e04083948f36496b5f6d182021-12-02T11:50:52ZClinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma1177-5483https://doaj.org/article/69d0152189e04083948f36496b5f6d182021-01-01T00:00:00Zhttps://www.dovepress.com/clinical-outcomes-of-micropulse-laser-trabeculoplasty-compared-to-sele-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Catherine Q Sun, Tiffany A Chen, Michael S Deiner, Yvonne Ou Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USACorrespondence: Catherine Q SunUCSF F.I. Proctor Foundation, 490 Illinois Street, Floor 2, San Francisco, CA 94143, USAEmail catherine.sun@ucsf.eduBackground: There is limited long-term data comparing selective laser trabeculoplasty (SLT) to the newer micropulse laser trabeculoplasty (MLT) using a laser emitting at 532 nm. In this study, we determine the effectiveness and safety of MLT compared to SLT.Design: Retrospective comparative cohort study.Participants: A total of 85 consecutive eyes received SLT and 43 consecutive eyes received MLT.Methods: Patients with open-angle glaucoma receiving their first treatment of laser trabeculoplasty were included. Exclusion criteria are prior laser trabeculoplasty, laser cyclophotocoagulation or glaucoma surgery, and follow-up of less than 1 year.Main Outcome Measures: The primary outcome was success at 1 year, defined as a reduction in intraocular eye pressure (IOP) by ≥ 20% from baseline or met prespecified target IOP with no additional glaucoma medication or subsequent glaucoma intervention.Results: Baseline IOP was 18.0 mmHg (95% CI=16.4– 19.5) in the MLT group on an average of 1.8 (95% CI=1.4– 2.2) glaucoma medications compared to 18.2 mmHg (95% CI=17.2– 19.3) for the SLT group on an average of 2.0 (95% CI=1.6– 2.3) medications. At 1-hour post-laser, the SLT group had more transient IOP spikes (MLT 5% vs SLT 16%, P=0.10). There was a trend toward increased success in the SLT group compared to MLT at 1 year (relative risk=1.4, 95% CI=0.8– 2.5, P=0.30).Conclusion and Relevance: Eyes had similar success after MLT compared to SLT at 1 year. Laser trabeculoplasty with either method could be offered as treatment with consideration of MLT in those eyes where IOP spikes should be avoided.Keywords: micropulse laser trabeculoplasty, selective laser trabeculoplasty, open-angle glaucomaSun CQChen TADeiner MSOu YDove Medical Pressarticlemicropulse laser trabeculoplastyselective laser trabeculoplastyopen-angle glaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 243-251 (2021) |
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micropulse laser trabeculoplasty selective laser trabeculoplasty open-angle glaucoma Ophthalmology RE1-994 |
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micropulse laser trabeculoplasty selective laser trabeculoplasty open-angle glaucoma Ophthalmology RE1-994 Sun CQ Chen TA Deiner MS Ou Y Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| description |
Catherine Q Sun, Tiffany A Chen, Michael S Deiner, Yvonne Ou Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USACorrespondence: Catherine Q SunUCSF F.I. Proctor Foundation, 490 Illinois Street, Floor 2, San Francisco, CA 94143, USAEmail catherine.sun@ucsf.eduBackground: There is limited long-term data comparing selective laser trabeculoplasty (SLT) to the newer micropulse laser trabeculoplasty (MLT) using a laser emitting at 532 nm. In this study, we determine the effectiveness and safety of MLT compared to SLT.Design: Retrospective comparative cohort study.Participants: A total of 85 consecutive eyes received SLT and 43 consecutive eyes received MLT.Methods: Patients with open-angle glaucoma receiving their first treatment of laser trabeculoplasty were included. Exclusion criteria are prior laser trabeculoplasty, laser cyclophotocoagulation or glaucoma surgery, and follow-up of less than 1 year.Main Outcome Measures: The primary outcome was success at 1 year, defined as a reduction in intraocular eye pressure (IOP) by ≥ 20% from baseline or met prespecified target IOP with no additional glaucoma medication or subsequent glaucoma intervention.Results: Baseline IOP was 18.0 mmHg (95% CI=16.4– 19.5) in the MLT group on an average of 1.8 (95% CI=1.4– 2.2) glaucoma medications compared to 18.2 mmHg (95% CI=17.2– 19.3) for the SLT group on an average of 2.0 (95% CI=1.6– 2.3) medications. At 1-hour post-laser, the SLT group had more transient IOP spikes (MLT 5% vs SLT 16%, P=0.10). There was a trend toward increased success in the SLT group compared to MLT at 1 year (relative risk=1.4, 95% CI=0.8– 2.5, P=0.30).Conclusion and Relevance: Eyes had similar success after MLT compared to SLT at 1 year. Laser trabeculoplasty with either method could be offered as treatment with consideration of MLT in those eyes where IOP spikes should be avoided.Keywords: micropulse laser trabeculoplasty, selective laser trabeculoplasty, open-angle glaucoma |
| format |
article |
| author |
Sun CQ Chen TA Deiner MS Ou Y |
| author_facet |
Sun CQ Chen TA Deiner MS Ou Y |
| author_sort |
Sun CQ |
| title |
Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| title_short |
Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| title_full |
Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| title_fullStr |
Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| title_full_unstemmed |
Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma |
| title_sort |
clinical outcomes of micropulse laser trabeculoplasty compared to selective laser trabeculoplasty at one year in open-angle glaucoma |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/69d0152189e04083948f36496b5f6d18 |
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