Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.

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Detalles Bibliográficos
Autores principales: Won Hoon Choi, Stefanie A. H. de Poot, Jung Hoon Lee, Ji Hyeon Kim, Dong Hoon Han, Yun Kyung Kim, Daniel Finley, Min Jae Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/69d5789905d74b3b8111cc7dc208f815
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Descripción
Sumario:The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.