Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.

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Autores principales:	Won Hoon Choi, Stefanie A. H. de Poot, Jung Hoon Lee, Ji Hyeon Kim, Dong Hoon Han, Yun Kyung Kim, Daniel Finley, Min Jae Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69d5789905d74b3b8111cc7dc208f815
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spelling	oai:doaj.org-article:69d5789905d74b3b8111cc7dc208f8152021-12-02T14:40:14ZOpen-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation10.1038/ncomms109632041-1723https://doaj.org/article/69d5789905d74b3b8111cc7dc208f8152016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10963https://doaj.org/toc/2041-1723The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.Won Hoon ChoiStefanie A. H. de PootJung Hoon LeeJi Hyeon KimDong Hoon HanYun Kyung KimDaniel FinleyMin Jae LeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Won Hoon Choi Stefanie A. H. de Poot Jung Hoon Lee Ji Hyeon Kim Dong Hoon Han Yun Kyung Kim Daniel Finley Min Jae Lee Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
description	The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.
format	article
author	Won Hoon Choi Stefanie A. H. de Poot Jung Hoon Lee Ji Hyeon Kim Dong Hoon Han Yun Kyung Kim Daniel Finley Min Jae Lee
author_facet	Won Hoon Choi Stefanie A. H. de Poot Jung Hoon Lee Ji Hyeon Kim Dong Hoon Han Yun Kyung Kim Daniel Finley Min Jae Lee
author_sort	Won Hoon Choi
title	Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
title_short	Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
title_full	Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
title_fullStr	Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
title_full_unstemmed	Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
title_sort	open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/69d5789905d74b3b8111cc7dc208f815
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Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

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