Hemostatic profile detailing in apparent VWD cases: A cross sectional study

The von willebrand disease (vWD) accounts to be one of the most common hereditary bleeding ailment that amounts its incidence to almost 1.5% of normal population. It is mostly associated with a defect in primary hemostasis as well as secondary defect in coagulation factor VIII as diagnosis of vwd ha...

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Autores principales:	Fatmah S. Alqahtany, Hanan B. ALBackr, Lateefa O. Aldakhil, Abdullah A. Alharbi, Nawaf Abdullah Alqahtani, Farjah H Algahtani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	von Willebrand Disease (vWD) Menorrhagia Bleeding disorder Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/69da3cc37a7c40d0afa133f580b01f78
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spelling	oai:doaj.org-article:69da3cc37a7c40d0afa133f580b01f782021-11-20T04:56:20ZHemostatic profile detailing in apparent VWD cases: A cross sectional study1319-562X10.1016/j.sjbs.2021.07.044https://doaj.org/article/69da3cc37a7c40d0afa133f580b01f782021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006173https://doaj.org/toc/1319-562XThe von willebrand disease (vWD) accounts to be one of the most common hereditary bleeding ailment that amounts its incidence to almost 1.5% of normal population. It is mostly associated with a defect in primary hemostasis as well as secondary defect in coagulation factor VIII as diagnosis of vwd happened to be challenging with earlier diagnostic criteria’s. Testing Vwd in menorrhagia patients was not at ease. A cross-sectional study was conducted in female patients who have visited obstetrics and gynecology clinic at King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia. The inclusion criteria consist of adult female patients between 16 and 45 years old with menorrhagia. A sample of 45 patients were screened and selected for the above-mentioned study. The SPSS Statistical analysis package was performed to analyze the data’s. The fisher’s exact test was conducted to compare the demographic variables. The independent samples t-test was conducted to compare the means of subjects. The P value of ≤0.05 considered as statistically significant. The cases manifested with a history of bleeding during periods stretching from 7 to 90 days. The vWD was reported in 6.6 % (n = 3) women out of the total 45 patients. The vWF: Ac mean ± SD (51.4 ± 6.3) and vWF: Ag Mean ± SD (93 ± 67) were significantly lesser in vWD patients with that of non-vWD (98.7 ± 22.6) vs (116 ± 42.4) (p = 0.027) (p = 0.032) respectively. WBC, ESR, MCV, MCH, Hemoglobin, PLT count, INR, PT, APTT and FVIII showed no significant difference among the groups (p > 0.05).Fatmah S. AlqahtanyHanan B. ALBackrLateefa O. AldakhilAbdullah A. AlharbiNawaf Abdullah AlqahtaniFarjah H AlgahtaniElsevierarticlevon Willebrand Disease (vWD)MenorrhagiaBleeding disorderBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6701-6704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	von Willebrand Disease (vWD) Menorrhagia Bleeding disorder Biology (General) QH301-705.5
spellingShingle	von Willebrand Disease (vWD) Menorrhagia Bleeding disorder Biology (General) QH301-705.5 Fatmah S. Alqahtany Hanan B. ALBackr Lateefa O. Aldakhil Abdullah A. Alharbi Nawaf Abdullah Alqahtani Farjah H Algahtani Hemostatic profile detailing in apparent VWD cases: A cross sectional study
description	The von willebrand disease (vWD) accounts to be one of the most common hereditary bleeding ailment that amounts its incidence to almost 1.5% of normal population. It is mostly associated with a defect in primary hemostasis as well as secondary defect in coagulation factor VIII as diagnosis of vwd happened to be challenging with earlier diagnostic criteria’s. Testing Vwd in menorrhagia patients was not at ease. A cross-sectional study was conducted in female patients who have visited obstetrics and gynecology clinic at King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia. The inclusion criteria consist of adult female patients between 16 and 45 years old with menorrhagia. A sample of 45 patients were screened and selected for the above-mentioned study. The SPSS Statistical analysis package was performed to analyze the data’s. The fisher’s exact test was conducted to compare the demographic variables. The independent samples t-test was conducted to compare the means of subjects. The P value of ≤0.05 considered as statistically significant. The cases manifested with a history of bleeding during periods stretching from 7 to 90 days. The vWD was reported in 6.6 % (n = 3) women out of the total 45 patients. The vWF: Ac mean ± SD (51.4 ± 6.3) and vWF: Ag Mean ± SD (93 ± 67) were significantly lesser in vWD patients with that of non-vWD (98.7 ± 22.6) vs (116 ± 42.4) (p = 0.027) (p = 0.032) respectively. WBC, ESR, MCV, MCH, Hemoglobin, PLT count, INR, PT, APTT and FVIII showed no significant difference among the groups (p > 0.05).
format	article
author	Fatmah S. Alqahtany Hanan B. ALBackr Lateefa O. Aldakhil Abdullah A. Alharbi Nawaf Abdullah Alqahtani Farjah H Algahtani
author_facet	Fatmah S. Alqahtany Hanan B. ALBackr Lateefa O. Aldakhil Abdullah A. Alharbi Nawaf Abdullah Alqahtani Farjah H Algahtani
author_sort	Fatmah S. Alqahtany
title	Hemostatic profile detailing in apparent VWD cases: A cross sectional study
title_short	Hemostatic profile detailing in apparent VWD cases: A cross sectional study
title_full	Hemostatic profile detailing in apparent VWD cases: A cross sectional study
title_fullStr	Hemostatic profile detailing in apparent VWD cases: A cross sectional study
title_full_unstemmed	Hemostatic profile detailing in apparent VWD cases: A cross sectional study
title_sort	hemostatic profile detailing in apparent vwd cases: a cross sectional study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/69da3cc37a7c40d0afa133f580b01f78
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Hemostatic profile detailing in apparent VWD cases: A cross sectional study

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