Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural...

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Autores principales:	Matthieu P.M.H. Benoit, Ana B. Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H. Kwok, Hernando Sosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69dab0e441714c2f9885f2595e096141
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spelling	oai:doaj.org-article:69dab0e441714c2f9885f2595e0961412021-12-02T17:23:48ZStructural basis of mechano-chemical coupling by the mitotic kinesin KIF1410.1038/s41467-021-23581-32041-1723https://doaj.org/article/69dab0e441714c2f9885f2595e0961412021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23581-3https://doaj.org/toc/2041-1723KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural basis for a coordinated chemo-mechanical kinesin translocation model.Matthieu P.M.H. BenoitAna B. AsenjoMohammadjavad PaydarSabin DhakalBenjamin H. KwokHernando SosaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthieu P.M.H. Benoit Ana B. Asenjo Mohammadjavad Paydar Sabin Dhakal Benjamin H. Kwok Hernando Sosa Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
description	KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural basis for a coordinated chemo-mechanical kinesin translocation model.
format	article
author	Matthieu P.M.H. Benoit Ana B. Asenjo Mohammadjavad Paydar Sabin Dhakal Benjamin H. Kwok Hernando Sosa
author_facet	Matthieu P.M.H. Benoit Ana B. Asenjo Mohammadjavad Paydar Sabin Dhakal Benjamin H. Kwok Hernando Sosa
author_sort	Matthieu P.M.H. Benoit
title	Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
title_short	Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
title_full	Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
title_fullStr	Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
title_full_unstemmed	Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
title_sort	structural basis of mechano-chemical coupling by the mitotic kinesin kif14
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69dab0e441714c2f9885f2595e096141
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Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

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