Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural...

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Autores principales: Matthieu P.M.H. Benoit, Ana B. Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H. Kwok, Hernando Sosa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/69dab0e441714c2f9885f2595e096141
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