Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus

Background: Metabolic and structural changes in cardiomyocytes in diabetes mellitus lead to aggravation of contractile myocardial dysfunction in coronary heart disease (CHD). The contractility dysfunction of cardiomyocytes is determined by a change in the levels of sarcoplasmic reticulum (SR) Ca2+-A...

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Autores principales:	Sergey A. Afanasiev, Dina S. Kondratieva, Margarita V. Egorova, Shamil D. Akhmedov, Olesya V. Budnikova, Sergey V. Popov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	coronary heart disease type 2 diabetes mellitus contractility of isolated trabeculae ca2+-atpase, succinate dehydrogenase lactate dehydrogenase oxidative phosphorylation Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/69dc4570b49b42e7be78f3ac1690c5d8
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spelling	oai:doaj.org-article:69dc4570b49b42e7be78f3ac1690c5d82021-11-14T09:00:22ZFeatures the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus2072-03512072-037810.14341/DM9735https://doaj.org/article/69dc4570b49b42e7be78f3ac1690c5d82019-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9735https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: Metabolic and structural changes in cardiomyocytes in diabetes mellitus lead to aggravation of contractile myocardial dysfunction in coronary heart disease (CHD). The contractility dysfunction of cardiomyocytes is determined by a change in the levels of sarcoplasmic reticulum (SR) Ca2+-ATPase and energetic supply of the cardiomyocytes. Aims: To study the features of functional remodeling of the heart muscle in coronary heart disease with and without type 2 diabetes mellitus (DM2) depend on the level of Ca2+-ATPase and the activity of enzymes involved in energy metabolism. Materials and methods: The work was performed on the heart biopsy of patients with CHD and patients with CHD combined with DM2. The inotropic reaction of myocardial strips on rest periods was assessed. The expression level of Ca2+-ATPase, the activity of enzymes succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) and the intensity of oxidative phosphorylation processes were determined. Results: The interval-force relationship in patients with CHD with and without DM2 had both negative and positive dynamics. The positive dynamics corresponds to the "high content" of the Ca2+-ATPase and the negative dynamics corresponds to the "low content" were found. At the combined pathology the positive inotropic dynamics is more pronounced and corresponds to a higher protein level. In the patients myocardium with CHD the activity of SDH and LDH was higher, while the oxygen uptake rate by mitochondria was higher in the myocardium with combined pathology. Conclusions: The potentiation of inotropic response of patient myocardium with CHD with and without DM2 corresponds to the "high level" of Ca2+-ATPase. In the combined pathology the inotropic capabilities of the myocardium are more expressed. In CHD the synthesis of ATP in cardiomyocytes is realized mainly due to glycolytic processes and Krebs cycle. In combined pathology the ATP synthesis is realized to a greater extent due to the oxidative phosphorylation.Sergey A. AfanasievDina S. KondratievaMargarita V. EgorovaShamil D. AkhmedovOlesya V. BudnikovaSergey V. PopovEndocrinology Research Centrearticlecoronary heart diseasetype 2 diabetes mellituscontractility of isolated trabeculaeca2+-atpase, succinate dehydrogenaselactate dehydrogenaseoxidative phosphorylationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 1, Pp 25-34 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	coronary heart disease type 2 diabetes mellitus contractility of isolated trabeculae ca2+-atpase, succinate dehydrogenase lactate dehydrogenase oxidative phosphorylation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	coronary heart disease type 2 diabetes mellitus contractility of isolated trabeculae ca2+-atpase, succinate dehydrogenase lactate dehydrogenase oxidative phosphorylation Nutritional diseases. Deficiency diseases RC620-627 Sergey A. Afanasiev Dina S. Kondratieva Margarita V. Egorova Shamil D. Akhmedov Olesya V. Budnikova Sergey V. Popov Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
description	Background: Metabolic and structural changes in cardiomyocytes in diabetes mellitus lead to aggravation of contractile myocardial dysfunction in coronary heart disease (CHD). The contractility dysfunction of cardiomyocytes is determined by a change in the levels of sarcoplasmic reticulum (SR) Ca2+-ATPase and energetic supply of the cardiomyocytes. Aims: To study the features of functional remodeling of the heart muscle in coronary heart disease with and without type 2 diabetes mellitus (DM2) depend on the level of Ca2+-ATPase and the activity of enzymes involved in energy metabolism. Materials and methods: The work was performed on the heart biopsy of patients with CHD and patients with CHD combined with DM2. The inotropic reaction of myocardial strips on rest periods was assessed. The expression level of Ca2+-ATPase, the activity of enzymes succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) and the intensity of oxidative phosphorylation processes were determined. Results: The interval-force relationship in patients with CHD with and without DM2 had both negative and positive dynamics. The positive dynamics corresponds to the "high content" of the Ca2+-ATPase and the negative dynamics corresponds to the "low content" were found. At the combined pathology the positive inotropic dynamics is more pronounced and corresponds to a higher protein level. In the patients myocardium with CHD the activity of SDH and LDH was higher, while the oxygen uptake rate by mitochondria was higher in the myocardium with combined pathology. Conclusions: The potentiation of inotropic response of patient myocardium with CHD with and without DM2 corresponds to the "high level" of Ca2+-ATPase. In the combined pathology the inotropic capabilities of the myocardium are more expressed. In CHD the synthesis of ATP in cardiomyocytes is realized mainly due to glycolytic processes and Krebs cycle. In combined pathology the ATP synthesis is realized to a greater extent due to the oxidative phosphorylation.
format	article
author	Sergey A. Afanasiev Dina S. Kondratieva Margarita V. Egorova Shamil D. Akhmedov Olesya V. Budnikova Sergey V. Popov
author_facet	Sergey A. Afanasiev Dina S. Kondratieva Margarita V. Egorova Shamil D. Akhmedov Olesya V. Budnikova Sergey V. Popov
author_sort	Sergey A. Afanasiev
title	Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
title_short	Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
title_full	Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
title_fullStr	Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
title_full_unstemmed	Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
title_sort	features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/69dc4570b49b42e7be78f3ac1690c5d8
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Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus

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