Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.

Surveillance is an integral part of tuberculosis (TB) control. Greece has a low TB notification rate, but there are doubts about underreporting. Examining anti-TB drug consumption is a way to validate the results of surveillance and estimate TB burden in the country. We used surveillance data from 2...

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Autores principales:	Theodore Lytras, Georgia Spala, Stefanos Bonovas, Takis Panagiotopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69dd70cc4f6248ceae772ae7730a503e
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spelling	oai:doaj.org-article:69dd70cc4f6248ceae772ae7730a503e2021-11-18T08:07:49ZEvaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.1932-620310.1371/journal.pone.0050033https://doaj.org/article/69dd70cc4f6248ceae772ae7730a503e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185524/?tool=EBIhttps://doaj.org/toc/1932-6203Surveillance is an integral part of tuberculosis (TB) control. Greece has a low TB notification rate, but there are doubts about underreporting. Examining anti-TB drug consumption is a way to validate the results of surveillance and estimate TB burden in the country. We used surveillance data from 2004 to 2008 to calculate the average prescribed treatment duration with the first-line anti-TB drugs isoniazid, rifampicin, ethambutol and pyrazinamide. We then obtained the best available data on consumption of these drugs, and calculated the number of treated cases to which these quantities correspond. We thus estimated underreporting at around 80% (77-81%), and annual TB incidence at about 30 cases per 100,000 population, five times over the notification rate. Underreporting was found to be constant over the study period, while incidence followed a decreasing trend. In addition we estimated that one person receives chemoprophylaxis for latent tuberculosis infection (LTBI) for every three TB cases. These results indicate the need for a comprehensive plan to improve TB surveillance and TB contact tracing in Greece, especially in light of the economic crisis affecting the country since 2009.Theodore LytrasGeorgia SpalaStefanos BonovasTakis PanagiotopoulosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50033 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Theodore Lytras Georgia Spala Stefanos Bonovas Takis Panagiotopoulos Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
description	Surveillance is an integral part of tuberculosis (TB) control. Greece has a low TB notification rate, but there are doubts about underreporting. Examining anti-TB drug consumption is a way to validate the results of surveillance and estimate TB burden in the country. We used surveillance data from 2004 to 2008 to calculate the average prescribed treatment duration with the first-line anti-TB drugs isoniazid, rifampicin, ethambutol and pyrazinamide. We then obtained the best available data on consumption of these drugs, and calculated the number of treated cases to which these quantities correspond. We thus estimated underreporting at around 80% (77-81%), and annual TB incidence at about 30 cases per 100,000 population, five times over the notification rate. Underreporting was found to be constant over the study period, while incidence followed a decreasing trend. In addition we estimated that one person receives chemoprophylaxis for latent tuberculosis infection (LTBI) for every three TB cases. These results indicate the need for a comprehensive plan to improve TB surveillance and TB contact tracing in Greece, especially in light of the economic crisis affecting the country since 2009.
format	article
author	Theodore Lytras Georgia Spala Stefanos Bonovas Takis Panagiotopoulos
author_facet	Theodore Lytras Georgia Spala Stefanos Bonovas Takis Panagiotopoulos
author_sort	Theodore Lytras
title	Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
title_short	Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
title_full	Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
title_fullStr	Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
title_full_unstemmed	Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.
title_sort	evaluation of tuberculosis underreporting in greece through comparison with anti-tuberculosis drug consumption.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/69dd70cc4f6248ceae772ae7730a503e
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Evaluation of tuberculosis underreporting in Greece through comparison with anti-tuberculosis drug consumption.

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