Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts

Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop an optogenetic tool for Plexin-B1 to show how thi...

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Autores principales:	Abhijit Deb Roy, Taofei Yin, Shilpa Choudhary, Vladimir Rodionov, Carol C. Pilbeam, Yi I. Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69de27093323428796da9c3cdb7c342a
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spelling	oai:doaj.org-article:69de27093323428796da9c3cdb7c342a2021-12-02T17:06:03ZOptogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts10.1038/ncomms158312041-1723https://doaj.org/article/69de27093323428796da9c3cdb7c342a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15831https://doaj.org/toc/2041-1723Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop an optogenetic tool for Plexin-B1 to show how this signalling axis induces cell repolarization.Abhijit Deb RoyTaofei YinShilpa ChoudharyVladimir RodionovCarol C. PilbeamYi I. WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abhijit Deb Roy Taofei Yin Shilpa Choudhary Vladimir Rodionov Carol C. Pilbeam Yi I. Wu Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
description	Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop an optogenetic tool for Plexin-B1 to show how this signalling axis induces cell repolarization.
format	article
author	Abhijit Deb Roy Taofei Yin Shilpa Choudhary Vladimir Rodionov Carol C. Pilbeam Yi I. Wu
author_facet	Abhijit Deb Roy Taofei Yin Shilpa Choudhary Vladimir Rodionov Carol C. Pilbeam Yi I. Wu
author_sort	Abhijit Deb Roy
title	Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
title_short	Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
title_full	Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
title_fullStr	Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
title_full_unstemmed	Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
title_sort	optogenetic activation of plexin-b1 reveals contact repulsion between osteoclasts and osteoblasts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69de27093323428796da9c3cdb7c342a
work_keys_str_mv	AT abhijitdebroy optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts AT taofeiyin optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts AT shilpachoudhary optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts AT vladimirrodionov optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts AT carolcpilbeam optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts AT yiiwu optogeneticactivationofplexinb1revealscontactrepulsionbetweenosteoclastsandosteoblasts
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Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts

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