Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in...
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Nature Portfolio
2019
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oai:doaj.org-article:69e3b05bacbb4d4db475ac38f90a9bda2021-12-02T14:38:44ZGenome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism10.1038/s41467-019-08492-82041-1723https://doaj.org/article/69e3b05bacbb4d4db475ac38f90a9bda2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08492-8https://doaj.org/toc/2041-1723Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies.Armand ValsesiaQiao-Ping WangNele GheldofJérôme CarayolHélène RuffieuxTeleri ClarkVictoria ShentonLisa J. OystonGregory LefebvreSylviane MetaironChristian ChabertOndine WalterPolina MironovaPaulina LauPatrick DescombesNathalie ViguerieDominique LanginMary-Ellen HarperArne AstrupWim H. SarisRobert DentGreg G. NeelyJörg HagerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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EN |
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Science Q |
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Science Q Armand Valsesia Qiao-Ping Wang Nele Gheldof Jérôme Carayol Hélène Ruffieux Teleri Clark Victoria Shenton Lisa J. Oyston Gregory Lefebvre Sylviane Metairon Christian Chabert Ondine Walter Polina Mironova Paulina Lau Patrick Descombes Nathalie Viguerie Dominique Langin Mary-Ellen Harper Arne Astrup Wim H. Saris Robert Dent Greg G. Neely Jörg Hager Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| description |
Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies. |
| format |
article |
| author |
Armand Valsesia Qiao-Ping Wang Nele Gheldof Jérôme Carayol Hélène Ruffieux Teleri Clark Victoria Shenton Lisa J. Oyston Gregory Lefebvre Sylviane Metairon Christian Chabert Ondine Walter Polina Mironova Paulina Lau Patrick Descombes Nathalie Viguerie Dominique Langin Mary-Ellen Harper Arne Astrup Wim H. Saris Robert Dent Greg G. Neely Jörg Hager |
| author_facet |
Armand Valsesia Qiao-Ping Wang Nele Gheldof Jérôme Carayol Hélène Ruffieux Teleri Clark Victoria Shenton Lisa J. Oyston Gregory Lefebvre Sylviane Metairon Christian Chabert Ondine Walter Polina Mironova Paulina Lau Patrick Descombes Nathalie Viguerie Dominique Langin Mary-Ellen Harper Arne Astrup Wim H. Saris Robert Dent Greg G. Neely Jörg Hager |
| author_sort |
Armand Valsesia |
| title |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| title_short |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| title_full |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| title_fullStr |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| title_full_unstemmed |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism |
| title_sort |
genome-wide gene-based analyses of weight loss interventions identify a potential role for nkx6.3 in metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/69e3b05bacbb4d4db475ac38f90a9bda |
| work_keys_str_mv |
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