Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology

The aim of this study was to study the molecular mechanisms of metabolic disorders that develop in highly productive cows. It was found that in the blood serum of animals with subclinical ketosis (SCK), which are in the eighth month of pregnancy, the concentration of β-hydroxybutyrate is increased,...

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Autores principales:	Skachkov Dmitry, Konvay Vladimir, Zabolotnykh Mikhail, Kornienko Ekaterina
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/69e3b6a8dcee4551a15af25fdb743a0a
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spelling	oai:doaj.org-article:69e3b6a8dcee4551a15af25fdb743a0a2021-11-08T15:17:16ZDisclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology2117-445810.1051/bioconf/20213700174https://doaj.org/article/69e3b6a8dcee4551a15af25fdb743a0a2021-01-01T00:00:00Zhttps://www.bio-conferences.org/articles/bioconf/pdf/2021/09/bioconf_fies2021_00174.pdfhttps://doaj.org/toc/2117-4458The aim of this study was to study the molecular mechanisms of metabolic disorders that develop in highly productive cows. It was found that in the blood serum of animals with subclinical ketosis (SCK), which are in the eighth month of pregnancy, the concentration of β-hydroxybutyrate is increased, the content of iron, calcium and phosphorus is reduced, its iron-binding capacity against the background of the absence of phenomena of hepatocellular insufficiency, violation of the integrity of hepatocytes, hypoplastic anemia. The aggravation of ketoacidosis in fresh cows with rumen acidosis is facilitated by the development of carbohydrate deficiency in them, due to their increased oxidation in the reactions of anaerobic glycolysis, accompanied by excessive catabolism of purine mononucleotides to uric acid. Excessive lipid peroxidation of membrane structures under conditions of increased catabolism of purine nucleotides, along with the accumulation of acylglycerols in the liver caused by cobalamin deficiency, leads to the development of syndromes of impaired hepatocyte integrity and hepatocellular insufficiency. A decrease in the liver's ability to store iron ions and synthesize proteins that provide an increase in the iron-binding capacity of blood plasma in conditions of cobalamin deficiency contributes to the development of hypoplastic anemia not only in cows, but also in calves born from them.Skachkov DmitryKonvay VladimirZabolotnykh MikhailKornienko EkaterinaEDP SciencesarticleMicrobiologyQR1-502PhysiologyQP1-981ZoologyQL1-991ENFRBIO Web of Conferences, Vol 37, p 00174 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
spellingShingle	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991 Skachkov Dmitry Konvay Vladimir Zabolotnykh Mikhail Kornienko Ekaterina Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
description	The aim of this study was to study the molecular mechanisms of metabolic disorders that develop in highly productive cows. It was found that in the blood serum of animals with subclinical ketosis (SCK), which are in the eighth month of pregnancy, the concentration of β-hydroxybutyrate is increased, the content of iron, calcium and phosphorus is reduced, its iron-binding capacity against the background of the absence of phenomena of hepatocellular insufficiency, violation of the integrity of hepatocytes, hypoplastic anemia. The aggravation of ketoacidosis in fresh cows with rumen acidosis is facilitated by the development of carbohydrate deficiency in them, due to their increased oxidation in the reactions of anaerobic glycolysis, accompanied by excessive catabolism of purine mononucleotides to uric acid. Excessive lipid peroxidation of membrane structures under conditions of increased catabolism of purine nucleotides, along with the accumulation of acylglycerols in the liver caused by cobalamin deficiency, leads to the development of syndromes of impaired hepatocyte integrity and hepatocellular insufficiency. A decrease in the liver's ability to store iron ions and synthesize proteins that provide an increase in the iron-binding capacity of blood plasma in conditions of cobalamin deficiency contributes to the development of hypoplastic anemia not only in cows, but also in calves born from them.
format	article
author	Skachkov Dmitry Konvay Vladimir Zabolotnykh Mikhail Kornienko Ekaterina
author_facet	Skachkov Dmitry Konvay Vladimir Zabolotnykh Mikhail Kornienko Ekaterina
author_sort	Skachkov Dmitry
title	Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
title_short	Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
title_full	Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
title_fullStr	Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
title_full_unstemmed	Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology
title_sort	disclosure of the mechanisms of metabolic disorders in highly productive cows as a way to improve milk production technology
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/69e3b6a8dcee4551a15af25fdb743a0a
work_keys_str_mv	AT skachkovdmitry disclosureofthemechanismsofmetabolicdisordersinhighlyproductivecowsasawaytoimprovemilkproductiontechnology AT konvayvladimir disclosureofthemechanismsofmetabolicdisordersinhighlyproductivecowsasawaytoimprovemilkproductiontechnology AT zabolotnykhmikhail disclosureofthemechanismsofmetabolicdisordersinhighlyproductivecowsasawaytoimprovemilkproductiontechnology AT kornienkoekaterina disclosureofthemechanismsofmetabolicdisordersinhighlyproductivecowsasawaytoimprovemilkproductiontechnology
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Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology

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