Sarcopenic obesity and cognitive performance

Magdalena I Tolea,1 Stephanie Chrisphonte,1 James E Galvin1,2 1Charles E. Schmidt College of Medicine, Department of Integrated Medical Sciences, Comprehensive Center for Brain Health, Florida Atlantic University, Boca Raton, FL, USA; 2Christine E. Lynn College of Nursing, Louis and Anne Green Memo...

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Autores principales:	Tolea MI, Chrisphonte S, Galvin JE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	sarcopenia obesity sarcopenic obesity cognition cross-sectional studies Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/69e5e56b04d94bd3816b8d2cbf47a35f
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spelling	oai:doaj.org-article:69e5e56b04d94bd3816b8d2cbf47a35f2021-12-02T07:59:43ZSarcopenic obesity and cognitive performance1178-1998https://doaj.org/article/69e5e56b04d94bd3816b8d2cbf47a35f2018-06-01T00:00:00Zhttps://www.dovepress.com/sarcopenic-obesity-and-cognitive-performance-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Magdalena I Tolea,1 Stephanie Chrisphonte,1 James E Galvin1,2 1Charles E. Schmidt College of Medicine, Department of Integrated Medical Sciences, Comprehensive Center for Brain Health, Florida Atlantic University, Boca Raton, FL, USA; 2Christine E. Lynn College of Nursing, Louis and Anne Green Memory and Wellness Center, Florida Atlantic University, Boca Raton, FL, USA Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Patients and methods: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements. Results: Sarcopenic obesity was associated with the lowest performance on global cognition (Est.Definition1=−2.85±1.38, p=0.039), followed by sarcopenia (Est.Definition1=−1.88±0.79, p=0.017) and obesity (Est.Definition1=−1.10±0.81, p=0.175) adjusted for sociodemographic factors. The latter, however, did not differ significantly from the comparison group consisting of older adults with neither sarcopenia nor obesity. Subdomain-specific analyses revealed executive function (Est.Definition1=−1.22±0.46 for sarcopenic obesity; Est.Definition1=−0.76±0.26 for sarcopenia; Est.Definition1=−0.52±0.27 for obesity all at p0.05) and orientation (Est.Definition1=0.59±0.26 for sarcopenic obesity; Est.Definition1=−0.36±0.15 for sarcopenia; Est.Definition1=−0.29±0.15 all but obesity significant at p<0.05) as the individual cognitive skills likely to be impacted. Potential age-specific and depression effects are discussed. Conclusion: Sarcopenia alone and in combination with sarcopenic obesity can be used in clinical practice as indicators of probable cognitive impairment. At-risk older adults may benefit from programs addressing loss of cognitive function by maintaining/improving strength and preventing obesity. Keywords: sarcopenia, obesity, sarcopenic obesity, cognition, cross-sectional studiesTolea MIChrisphonte SGalvin JEDove Medical Pressarticlesarcopeniaobesitysarcopenic obesitycognitioncross-sectional studiesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1111-1119 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia obesity sarcopenic obesity cognition cross-sectional studies Geriatrics RC952-954.6
spellingShingle	sarcopenia obesity sarcopenic obesity cognition cross-sectional studies Geriatrics RC952-954.6 Tolea MI Chrisphonte S Galvin JE Sarcopenic obesity and cognitive performance
description	Magdalena I Tolea,1 Stephanie Chrisphonte,1 James E Galvin1,2 1Charles E. Schmidt College of Medicine, Department of Integrated Medical Sciences, Comprehensive Center for Brain Health, Florida Atlantic University, Boca Raton, FL, USA; 2Christine E. Lynn College of Nursing, Louis and Anne Green Memory and Wellness Center, Florida Atlantic University, Boca Raton, FL, USA Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Patients and methods: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements. Results: Sarcopenic obesity was associated with the lowest performance on global cognition (Est.Definition1=−2.85±1.38, p=0.039), followed by sarcopenia (Est.Definition1=−1.88±0.79, p=0.017) and obesity (Est.Definition1=−1.10±0.81, p=0.175) adjusted for sociodemographic factors. The latter, however, did not differ significantly from the comparison group consisting of older adults with neither sarcopenia nor obesity. Subdomain-specific analyses revealed executive function (Est.Definition1=−1.22±0.46 for sarcopenic obesity; Est.Definition1=−0.76±0.26 for sarcopenia; Est.Definition1=−0.52±0.27 for obesity all at p0.05) and orientation (Est.Definition1=0.59±0.26 for sarcopenic obesity; Est.Definition1=−0.36±0.15 for sarcopenia; Est.Definition1=−0.29±0.15 all but obesity significant at p<0.05) as the individual cognitive skills likely to be impacted. Potential age-specific and depression effects are discussed. Conclusion: Sarcopenia alone and in combination with sarcopenic obesity can be used in clinical practice as indicators of probable cognitive impairment. At-risk older adults may benefit from programs addressing loss of cognitive function by maintaining/improving strength and preventing obesity. Keywords: sarcopenia, obesity, sarcopenic obesity, cognition, cross-sectional studies
format	article
author	Tolea MI Chrisphonte S Galvin JE
author_facet	Tolea MI Chrisphonte S Galvin JE
author_sort	Tolea MI
title	Sarcopenic obesity and cognitive performance
title_short	Sarcopenic obesity and cognitive performance
title_full	Sarcopenic obesity and cognitive performance
title_fullStr	Sarcopenic obesity and cognitive performance
title_full_unstemmed	Sarcopenic obesity and cognitive performance
title_sort	sarcopenic obesity and cognitive performance
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/69e5e56b04d94bd3816b8d2cbf47a35f
work_keys_str_mv	AT toleami sarcopenicobesityandcognitiveperformance AT chrisphontes sarcopenicobesityandcognitiveperformance AT galvinje sarcopenicobesityandcognitiveperformance
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Sarcopenic obesity and cognitive performance

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