Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice

A large-scale epidemic of type 2 diabetes mellitus (T2DM) is observed with advanced ageing worldwide. The prevalence of T2DM significantly increases with age. Therefore, this review aimed to summarise the data on T2DM in advanced and older aged patients. The primary geriatric syndromes, which should...

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Autor principal:	Elena V. Biryukova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	diabetes mellitus type 2 elderly advanced age geriatric syndromes hypoglycemia hypoglycemic therapy dpp-4 inhibitors sitagliptin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/69e77b3ea38c432496c1c78c634e0c57
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spelling	oai:doaj.org-article:69e77b3ea38c432496c1c78c634e0c572021-11-14T09:00:22ZType 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice2072-03512072-037810.14341/DM10315https://doaj.org/article/69e77b3ea38c432496c1c78c634e0c572019-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10315https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378A large-scale epidemic of type 2 diabetes mellitus (T2DM) is observed with advanced ageing worldwide. The prevalence of T2DM significantly increases with age. Therefore, this review aimed to summarise the data on T2DM in advanced and older aged patients. The primary geriatric syndromes, which should be considered for the management of older patients (cognitive impairment, sarcopenia, orthostatic hypotension, falls, urinary incontinence, senile asthenia, etc.), are presented. The causes of the high risk for hypoglycaemia in elderly patients are analysed. Improving the treatment for T2DM is a priority of modern medicine. Using antihyperglycaemic therapy is especially difficult in this population due to the high risk of hypoglycaemia and the multi-organ pathology leading to polypharmacy. Therefore, special attention is paid to treatment recommendations. Hypoglycaemic drugs used in elderly patients should be low risk of hypoglycaemia, without nephro- and hepatic toxicity, safe for cardiovascular organs, easy to administer. Furthermore, advantages and limitations of using various groups of hypoglycaemic drugs in elderly patients are discussed. DPP-4 inhibitors are also considered in detail. Modern data on mechanisms of hypoglycaemic action of DPP-4 inhibitors are presented. Possibilities of using sitagliptin in elderly patients were also considered. Finally, evidence-based studies demonstrating the obvious advantages of sitagliptin for the treatment of T2DM in the elderly and advanced aged population are discussed.Elena V. BiryukovaEndocrinology Research Centrearticlediabetes mellitus type 2elderlyadvanced agegeriatric syndromeshypoglycemiahypoglycemic therapydpp-4 inhibitorssitagliptinNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 6, Pp 582-591 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 2 elderly advanced age geriatric syndromes hypoglycemia hypoglycemic therapy dpp-4 inhibitors sitagliptin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 2 elderly advanced age geriatric syndromes hypoglycemia hypoglycemic therapy dpp-4 inhibitors sitagliptin Nutritional diseases. Deficiency diseases RC620-627 Elena V. Biryukova Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
description	A large-scale epidemic of type 2 diabetes mellitus (T2DM) is observed with advanced ageing worldwide. The prevalence of T2DM significantly increases with age. Therefore, this review aimed to summarise the data on T2DM in advanced and older aged patients. The primary geriatric syndromes, which should be considered for the management of older patients (cognitive impairment, sarcopenia, orthostatic hypotension, falls, urinary incontinence, senile asthenia, etc.), are presented. The causes of the high risk for hypoglycaemia in elderly patients are analysed. Improving the treatment for T2DM is a priority of modern medicine. Using antihyperglycaemic therapy is especially difficult in this population due to the high risk of hypoglycaemia and the multi-organ pathology leading to polypharmacy. Therefore, special attention is paid to treatment recommendations. Hypoglycaemic drugs used in elderly patients should be low risk of hypoglycaemia, without nephro- and hepatic toxicity, safe for cardiovascular organs, easy to administer. Furthermore, advantages and limitations of using various groups of hypoglycaemic drugs in elderly patients are discussed. DPP-4 inhibitors are also considered in detail. Modern data on mechanisms of hypoglycaemic action of DPP-4 inhibitors are presented. Possibilities of using sitagliptin in elderly patients were also considered. Finally, evidence-based studies demonstrating the obvious advantages of sitagliptin for the treatment of T2DM in the elderly and advanced aged population are discussed.
format	article
author	Elena V. Biryukova
author_facet	Elena V. Biryukova
author_sort	Elena V. Biryukova
title	Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
title_short	Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
title_full	Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
title_fullStr	Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
title_full_unstemmed	Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
title_sort	type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/69e77b3ea38c432496c1c78c634e0c57
work_keys_str_mv	AT elenavbiryukova type2diabetesmellitusinelderlypatientstreatedwithendocrinologistsinclinicalpractice
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Type 2 diabetes mellitus in elderly patients treated with endocrinologists in clinical practice

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