Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality
Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial s...
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Nature Portfolio
2021
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oai:doaj.org-article:69e79bb73bcb4e36b06bc36a2df150112021-12-02T11:39:43ZMyoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality10.1038/s41598-021-85426-92045-2322https://doaj.org/article/69e79bb73bcb4e36b06bc36a2df150112021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85426-9https://doaj.org/toc/2045-2322Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial symptoms, comorbidities and laboratory evaluation of patients, diagnosed with COVID-19 in Huoshenshan Hospital, Wuhan, from 4th February to 12th March, 2020. Based on the data collected from 63 severely ill patients from the onset of symptoms till the full recovery or demise, we found not only age (average 70) but also blood indicators as significant risk factors associated with multiple organ failure. The blood indices of all patients showed hepatic, renal, cardiac and hematopoietic dysfunction with imbalanced coagulatory biomarkers. We noticed that the levels of LDH (85%, P < .001), HBDH (76%, P < .001) and CRP (65%, P < .001) were significantly elevated in deceased patients, indicating hepatic impairment. Similarly, increased CK (15%, P = .002), Cre (37%, P = 0.102) and CysC (74%, P = 0.384) indicated renal damage. Cardiac injury was obvious from the significantly elevated level of Myoglobin (52%, P < .01), Troponin-I (65%, P = 0.273) and BNP (50%, P = .787). SARS-CoV-2 disturbs the hemolymphatic system as WBC# (73%, P = .002) and NEUT# (78%, P < .001) were significantly elevated in deceased patients. Likewise, the level of D-dimer (80%, P < .171), PT (87%, P = .031) and TT (57%, P = .053) was elevated, indicating coagulatory imbalances. We identified myoglobin and CRP as specific risk factors related to mortality and highly correlated to organ failure in COVID-19 disease.Ashaq AliMuhammad NomanYong GuoXu LiuRong ZhangJuan ZhouYang ZhengXian-En ZhangYong QiXiaohua ChenDong MenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| description |
Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial symptoms, comorbidities and laboratory evaluation of patients, diagnosed with COVID-19 in Huoshenshan Hospital, Wuhan, from 4th February to 12th March, 2020. Based on the data collected from 63 severely ill patients from the onset of symptoms till the full recovery or demise, we found not only age (average 70) but also blood indicators as significant risk factors associated with multiple organ failure. The blood indices of all patients showed hepatic, renal, cardiac and hematopoietic dysfunction with imbalanced coagulatory biomarkers. We noticed that the levels of LDH (85%, P < .001), HBDH (76%, P < .001) and CRP (65%, P < .001) were significantly elevated in deceased patients, indicating hepatic impairment. Similarly, increased CK (15%, P = .002), Cre (37%, P = 0.102) and CysC (74%, P = 0.384) indicated renal damage. Cardiac injury was obvious from the significantly elevated level of Myoglobin (52%, P < .01), Troponin-I (65%, P = 0.273) and BNP (50%, P = .787). SARS-CoV-2 disturbs the hemolymphatic system as WBC# (73%, P = .002) and NEUT# (78%, P < .001) were significantly elevated in deceased patients. Likewise, the level of D-dimer (80%, P < .171), PT (87%, P = .031) and TT (57%, P = .053) was elevated, indicating coagulatory imbalances. We identified myoglobin and CRP as specific risk factors related to mortality and highly correlated to organ failure in COVID-19 disease. |
| format |
article |
| author |
Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men |
| author_facet |
Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men |
| author_sort |
Ashaq Ali |
| title |
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_short |
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_full |
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_fullStr |
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_full_unstemmed |
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_sort |
myoglobin and c-reactive protein are efficient and reliable early predictors of covid-19 associated mortality |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/69e79bb73bcb4e36b06bc36a2df15011 |
| work_keys_str_mv |
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