Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with genetic compartmentalization, and the onset of metabolic...

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Autores principales:	Virginia S. Lioy, Jean-Noël Lorenzi, Soumaya Najah, Thibault Poinsignon, Hervé Leh, Corinne Saulnier, Bertrand Aigle, Sylvie Lautru, Annabelle Thibessard, Olivier Lespinet, Pierre Leblond, Yan Jaszczyszyn, Kevin Gorrichon, Nelle Varoquaux, Ivan Junier, Frédéric Boccard, Jean-Luc Pernodet, Stéphanie Bury-Moné
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69ebdcca68044d26ae4c0c82ce1b8f3e
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spelling	oai:doaj.org-article:69ebdcca68044d26ae4c0c82ce1b8f3e2021-12-02T19:10:37ZDynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation10.1038/s41467-021-25462-12041-1723https://doaj.org/article/69ebdcca68044d26ae4c0c82ce1b8f3e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25462-1https://doaj.org/toc/2041-1723Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with genetic compartmentalization, and the onset of metabolic differentiation is accompanied by a rearrangement of chromosome architecture.Virginia S. LioyJean-Noël LorenziSoumaya NajahThibault PoinsignonHervé LehCorinne SaulnierBertrand AigleSylvie LautruAnnabelle ThibessardOlivier LespinetPierre LeblondYan JaszczyszynKevin GorrichonNelle VaroquauxIvan JunierFrédéric BoccardJean-Luc PernodetStéphanie Bury-MonéNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Virginia S. Lioy Jean-Noël Lorenzi Soumaya Najah Thibault Poinsignon Hervé Leh Corinne Saulnier Bertrand Aigle Sylvie Lautru Annabelle Thibessard Olivier Lespinet Pierre Leblond Yan Jaszczyszyn Kevin Gorrichon Nelle Varoquaux Ivan Junier Frédéric Boccard Jean-Luc Pernodet Stéphanie Bury-Moné Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
description	Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with genetic compartmentalization, and the onset of metabolic differentiation is accompanied by a rearrangement of chromosome architecture.
format	article
author	Virginia S. Lioy Jean-Noël Lorenzi Soumaya Najah Thibault Poinsignon Hervé Leh Corinne Saulnier Bertrand Aigle Sylvie Lautru Annabelle Thibessard Olivier Lespinet Pierre Leblond Yan Jaszczyszyn Kevin Gorrichon Nelle Varoquaux Ivan Junier Frédéric Boccard Jean-Luc Pernodet Stéphanie Bury-Moné
author_facet	Virginia S. Lioy Jean-Noël Lorenzi Soumaya Najah Thibault Poinsignon Hervé Leh Corinne Saulnier Bertrand Aigle Sylvie Lautru Annabelle Thibessard Olivier Lespinet Pierre Leblond Yan Jaszczyszyn Kevin Gorrichon Nelle Varoquaux Ivan Junier Frédéric Boccard Jean-Luc Pernodet Stéphanie Bury-Moné
author_sort	Virginia S. Lioy
title	Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
title_short	Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
title_full	Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
title_fullStr	Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
title_full_unstemmed	Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
title_sort	dynamics of the compartmentalized streptomyces chromosome during metabolic differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69ebdcca68044d26ae4c0c82ce1b8f3e
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Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

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