Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives

Pleuromutilin derivatives are potent antibacterial drugs obtained from Basidiomycete fungi. Here, the authors report the genetic characterisation of the steps involved in pleuromutilin biosynthesis through heterologous expression and generate a semi-synthetic pleuromutilin derivative with enhanced a...

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Autores principales:	Fabrizio Alberti, Khairunisa Khairudin, Edith Rodriguez Venegas, Jonathan A. Davies, Patrick M. Hayes, Christine L. Willis, Andy M. Bailey, Gary D. Foster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69ed545afbdf4bf8aca81334cecd634a
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spelling	oai:doaj.org-article:69ed545afbdf4bf8aca81334cecd634a2021-12-02T17:06:03ZHeterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives10.1038/s41467-017-01659-12041-1723https://doaj.org/article/69ed545afbdf4bf8aca81334cecd634a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01659-1https://doaj.org/toc/2041-1723Pleuromutilin derivatives are potent antibacterial drugs obtained from Basidiomycete fungi. Here, the authors report the genetic characterisation of the steps involved in pleuromutilin biosynthesis through heterologous expression and generate a semi-synthetic pleuromutilin derivative with enhanced antibiotic activity.Fabrizio AlbertiKhairunisa KhairudinEdith Rodriguez VenegasJonathan A. DaviesPatrick M. HayesChristine L. WillisAndy M. BaileyGary D. FosterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabrizio Alberti Khairunisa Khairudin Edith Rodriguez Venegas Jonathan A. Davies Patrick M. Hayes Christine L. Willis Andy M. Bailey Gary D. Foster Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
description	Pleuromutilin derivatives are potent antibacterial drugs obtained from Basidiomycete fungi. Here, the authors report the genetic characterisation of the steps involved in pleuromutilin biosynthesis through heterologous expression and generate a semi-synthetic pleuromutilin derivative with enhanced antibiotic activity.
format	article
author	Fabrizio Alberti Khairunisa Khairudin Edith Rodriguez Venegas Jonathan A. Davies Patrick M. Hayes Christine L. Willis Andy M. Bailey Gary D. Foster
author_facet	Fabrizio Alberti Khairunisa Khairudin Edith Rodriguez Venegas Jonathan A. Davies Patrick M. Hayes Christine L. Willis Andy M. Bailey Gary D. Foster
author_sort	Fabrizio Alberti
title	Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
title_short	Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
title_full	Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
title_fullStr	Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
title_full_unstemmed	Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
title_sort	heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69ed545afbdf4bf8aca81334cecd634a
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Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives

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