CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.

The purposes of the study were to determine whether there are differences in texture analysis parameters between tonsil cancers and normal tonsils, and to correlate texture analysis with 18F-FDG PET/CT to investigate the relationship between texture analysis and metabolic parameters. Sixty-four pati...

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Autores principales:	Tae-Yoon Kim, Ji Young Lee, Young-Jun Lee, Dong Woo Park, Kyung Tae, Yun Young Choi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69edbb1702e140edac50cb9547c52cf4
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spelling	oai:doaj.org-article:69edbb1702e140edac50cb9547c52cf42021-12-02T20:18:25ZCT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.1932-620310.1371/journal.pone.0255835https://doaj.org/article/69edbb1702e140edac50cb9547c52cf42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255835https://doaj.org/toc/1932-6203The purposes of the study were to determine whether there are differences in texture analysis parameters between tonsil cancers and normal tonsils, and to correlate texture analysis with 18F-FDG PET/CT to investigate the relationship between texture analysis and metabolic parameters. Sixty-four patients with squamous cell carcinoma of the palatine tonsil were included. A ROI was drawn, including all slices, to involve the entire tumor. The contralateral normal tonsil was used for comparison with the tumors. Texture analysis parameters, mean, standard deviation (SD), entropy, mean positive pixels, skewness, and kurtosis were obtained using commercially available software. Parameters were compared between the tumor and the normal palatine tonsils. Comparisons were also performed among early tonsil cancer, advanced tonsil cancer, and normal tonsils. An ROC curve analysis was performed to assess discrimination of tumor from normal tonsils. Correlation between texture analysis and 18F-FDG PET/CT was performed. Compared to normal tonsils, the tumors showed a significantly lower mean, higher SD, higher entropy, lower skewness, and higher kurtosis on most filters (p<0.001). On comparisons among normal tonsils, early cancers, and advanced tonsil cancers, SD and entropy showed significantly higher values on all filters (p<0.001) between early cancers and normal tonsils. The AUC from the ROC analysis was 0.91, obtained from the entropy. A mild correlation was shown between texture parameters and metabolic parameters. The texture analysis parameters, especially entropy, showed significant differences in contrast-enhanced CT results between tumor and normal tonsils, and between early tonsil cancers and normal tonsils. Texture analysis can be useful as an adjunctive tool for the diagnosis of tonsil cancers.Tae-Yoon KimJi Young LeeYoung-Jun LeeDong Woo ParkKyung TaeYun Young ChoiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255835 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae-Yoon Kim Ji Young Lee Young-Jun Lee Dong Woo Park Kyung Tae Yun Young Choi CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
description	The purposes of the study were to determine whether there are differences in texture analysis parameters between tonsil cancers and normal tonsils, and to correlate texture analysis with 18F-FDG PET/CT to investigate the relationship between texture analysis and metabolic parameters. Sixty-four patients with squamous cell carcinoma of the palatine tonsil were included. A ROI was drawn, including all slices, to involve the entire tumor. The contralateral normal tonsil was used for comparison with the tumors. Texture analysis parameters, mean, standard deviation (SD), entropy, mean positive pixels, skewness, and kurtosis were obtained using commercially available software. Parameters were compared between the tumor and the normal palatine tonsils. Comparisons were also performed among early tonsil cancer, advanced tonsil cancer, and normal tonsils. An ROC curve analysis was performed to assess discrimination of tumor from normal tonsils. Correlation between texture analysis and 18F-FDG PET/CT was performed. Compared to normal tonsils, the tumors showed a significantly lower mean, higher SD, higher entropy, lower skewness, and higher kurtosis on most filters (p<0.001). On comparisons among normal tonsils, early cancers, and advanced tonsil cancers, SD and entropy showed significantly higher values on all filters (p<0.001) between early cancers and normal tonsils. The AUC from the ROC analysis was 0.91, obtained from the entropy. A mild correlation was shown between texture parameters and metabolic parameters. The texture analysis parameters, especially entropy, showed significant differences in contrast-enhanced CT results between tumor and normal tonsils, and between early tonsil cancers and normal tonsils. Texture analysis can be useful as an adjunctive tool for the diagnosis of tonsil cancers.
format	article
author	Tae-Yoon Kim Ji Young Lee Young-Jun Lee Dong Woo Park Kyung Tae Yun Young Choi
author_facet	Tae-Yoon Kim Ji Young Lee Young-Jun Lee Dong Woo Park Kyung Tae Yun Young Choi
author_sort	Tae-Yoon Kim
title	CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
title_short	CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
title_full	CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
title_fullStr	CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
title_full_unstemmed	CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.
title_sort	ct texture analysis of tonsil cancer: discrimination from normal palatine tonsils.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/69edbb1702e140edac50cb9547c52cf4
work_keys_str_mv	AT taeyoonkim cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils AT jiyounglee cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils AT youngjunlee cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils AT dongwoopark cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils AT kyungtae cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils AT yunyoungchoi cttextureanalysisoftonsilcancerdiscriminationfromnormalpalatinetonsils
_version_	1718374288629694464

CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils.

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