Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 si...

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Autores principales: Cheng Wang, Wenjing Xu, Jie An, Minglu Liang, Yiqing Li, Fengxiao Zhang, Qiangsong Tong, Kai Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/69ede5d3fbeb44789640a5683cea514a
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spelling oai:doaj.org-article:69ede5d3fbeb44789640a5683cea514a2021-12-02T14:39:55ZPoly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx210.1038/s41467-019-09174-12041-1723https://doaj.org/article/69ede5d3fbeb44789640a5683cea514a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09174-1https://doaj.org/toc/2041-1723Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.Cheng WangWenjing XuJie AnMinglu LiangYiqing LiFengxiao ZhangQiangsong TongKai HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
description Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.
format article
author Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
author_facet Cheng Wang
Wenjing Xu
Jie An
Minglu Liang
Yiqing Li
Fengxiao Zhang
Qiangsong Tong
Kai Huang
author_sort Cheng Wang
title Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_short Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_full Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_fullStr Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_full_unstemmed Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
title_sort poly(adp-ribose) polymerase 1 accelerates vascular calcification by upregulating runx2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/69ede5d3fbeb44789640a5683cea514a
work_keys_str_mv AT chengwang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT wenjingxu polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT jiean polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT mingluliang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT yiqingli polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT fengxiaozhang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT qiangsongtong polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
AT kaihuang polyadpribosepolymerase1acceleratesvascularcalcificationbyupregulatingrunx2
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