GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:69f154ad67fa47219da5b76adf207d5e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:69f154ad67fa47219da5b76adf207d5e2021-12-02T17:32:51ZGATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate10.1038/ncomms111712041-1723https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11171https://doaj.org/toc/2041-1723Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme.Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De SmedtBart VandekerckhoveTessa KerreJean PlumGeorges LeclercqEllen V. RothenbergPieter Van VlierbergheFrank SpelemanTom TaghonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Inge Van de Walle Anne-Catherine Dolens Kaat Durinck Katrien De Mulder Wouter Van Loocke Sagar Damle Els Waegemans Jelle De Medts Imke Velghe Magda De Smedt Bart Vandekerckhove Tessa Kerre Jean Plum Georges Leclercq Ellen V. Rothenberg Pieter Van Vlierberghe Frank Speleman Tom Taghon GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| description |
Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme. |
| format |
article |
| author |
Inge Van de Walle Anne-Catherine Dolens Kaat Durinck Katrien De Mulder Wouter Van Loocke Sagar Damle Els Waegemans Jelle De Medts Imke Velghe Magda De Smedt Bart Vandekerckhove Tessa Kerre Jean Plum Georges Leclercq Ellen V. Rothenberg Pieter Van Vlierberghe Frank Speleman Tom Taghon |
| author_facet |
Inge Van de Walle Anne-Catherine Dolens Kaat Durinck Katrien De Mulder Wouter Van Loocke Sagar Damle Els Waegemans Jelle De Medts Imke Velghe Magda De Smedt Bart Vandekerckhove Tessa Kerre Jean Plum Georges Leclercq Ellen V. Rothenberg Pieter Van Vlierberghe Frank Speleman Tom Taghon |
| author_sort |
Inge Van de Walle |
| title |
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| title_short |
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| title_full |
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| title_fullStr |
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| title_full_unstemmed |
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate |
| title_sort |
gata3 induces human t-cell commitment by restraining notch activity and repressing nk-cell fate |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e |
| work_keys_str_mv |
AT ingevandewalle gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT annecatherinedolens gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT kaatdurinck gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT katriendemulder gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT woutervanloocke gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT sagardamle gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT elswaegemans gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT jelledemedts gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT imkevelghe gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT magdadesmedt gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT bartvandekerckhove gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT tessakerre gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT jeanplum gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT georgesleclercq gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT ellenvrothenberg gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT pietervanvlierberghe gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT frankspeleman gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate AT tomtaghon gata3induceshumantcellcommitmentbyrestrainingnotchactivityandrepressingnkcellfate |
| _version_ |
1718380191420514304 |