BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm

Abstract Background While some studies suggest that the BRAF V600E mutation correlates with a high-risk phenotype in papillary thyroid microcarcinoma (PTMC), more evidence is necessary before this mutation can be used to help guide decision making in the management of small thyroid nodules. This stu...

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Autores principales: Jennifer A. Silver, Mariya Bogatchenko, Marc Pusztaszeri, Véronique-Isabelle Forest, Michael P. Hier, Ji Wei Yang, Michael Tamilia, Richard J. Payne
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Publicado: BMC 2021
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spelling oai:doaj.org-article:69f36f0391804101aeee2d7d2f4dce8f2021-11-07T12:15:20ZBRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm10.1186/s40463-021-00543-91916-0216https://doaj.org/article/69f36f0391804101aeee2d7d2f4dce8f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40463-021-00543-9https://doaj.org/toc/1916-0216Abstract Background While some studies suggest that the BRAF V600E mutation correlates with a high-risk phenotype in papillary thyroid microcarcinoma (PTMC), more evidence is necessary before this mutation can be used to help guide decision making in the management of small thyroid nodules. This study investigated whether BRAF V600E mutation is associated with aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Methods Retrospective chart review was performed on 121 patient cases. Patients who underwent thyroid surgery for PTMC (≤ 1 cm) or small PTC (1–1.5 cm) were included if molecular testing was done for BRAF V600E mutation. Two study groups were created based on tumour size: PTMC (n = 55) and small PTC (n = 66). The groups were analysed for the presence of a BRAF V600E mutation and aggressive features, including macroscopic extrathyroidal extension (ETE), lymph node metastasis (LNM), and high-risk histological features (tall cell, columnar cell, hobnail, solid/trabecular, and diffuse sclerosing). The Fischer exact test was used to calculate statistical significance. Results BRAF V600E mutations were detected in 43.6% of PTMC and 42.4% of small PTC. Of the mutated PTMC nodules, 54.1% demonstrated aggressive characteristics as compared to 19.4% of the non-mutated PTMCs (p = 0.010). Of the mutated small PTC tumours, 82.1% had aggressive features. In contrast, 28.9% of the non-mutated small PTCs showed aggressive features (p < 0.001). Conclusions Our findings demonstrate an association between a BRAF V600E mutation and aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Therefore, determining the molecular status of these thyroid nodules for the presence of BRAF V600E can help guide patient management. Graphical AbstractJennifer A. SilverMariya BogatchenkoMarc PusztaszeriVéronique-Isabelle ForestMichael P. HierJi Wei YangMichael TamiliaRichard J. PayneBMCarticlePapillary thyroid microcarcinomaBRAF V600E mutationClinicopathologic featuresThyroid cancerSurgeryRD1-811ENJournal of Otolaryngology - Head and Neck Surgery, Vol 50, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Papillary thyroid microcarcinoma
BRAF V600E mutation
Clinicopathologic features
Thyroid cancer
Surgery
RD1-811
spellingShingle Papillary thyroid microcarcinoma
BRAF V600E mutation
Clinicopathologic features
Thyroid cancer
Surgery
RD1-811
Jennifer A. Silver
Mariya Bogatchenko
Marc Pusztaszeri
Véronique-Isabelle Forest
Michael P. Hier
Ji Wei Yang
Michael Tamilia
Richard J. Payne
BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
description Abstract Background While some studies suggest that the BRAF V600E mutation correlates with a high-risk phenotype in papillary thyroid microcarcinoma (PTMC), more evidence is necessary before this mutation can be used to help guide decision making in the management of small thyroid nodules. This study investigated whether BRAF V600E mutation is associated with aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Methods Retrospective chart review was performed on 121 patient cases. Patients who underwent thyroid surgery for PTMC (≤ 1 cm) or small PTC (1–1.5 cm) were included if molecular testing was done for BRAF V600E mutation. Two study groups were created based on tumour size: PTMC (n = 55) and small PTC (n = 66). The groups were analysed for the presence of a BRAF V600E mutation and aggressive features, including macroscopic extrathyroidal extension (ETE), lymph node metastasis (LNM), and high-risk histological features (tall cell, columnar cell, hobnail, solid/trabecular, and diffuse sclerosing). The Fischer exact test was used to calculate statistical significance. Results BRAF V600E mutations were detected in 43.6% of PTMC and 42.4% of small PTC. Of the mutated PTMC nodules, 54.1% demonstrated aggressive characteristics as compared to 19.4% of the non-mutated PTMCs (p = 0.010). Of the mutated small PTC tumours, 82.1% had aggressive features. In contrast, 28.9% of the non-mutated small PTCs showed aggressive features (p < 0.001). Conclusions Our findings demonstrate an association between a BRAF V600E mutation and aggressive features in PTMC (≤ 1 cm) and small PTC (1–1.5 cm). Therefore, determining the molecular status of these thyroid nodules for the presence of BRAF V600E can help guide patient management. Graphical Abstract
format article
author Jennifer A. Silver
Mariya Bogatchenko
Marc Pusztaszeri
Véronique-Isabelle Forest
Michael P. Hier
Ji Wei Yang
Michael Tamilia
Richard J. Payne
author_facet Jennifer A. Silver
Mariya Bogatchenko
Marc Pusztaszeri
Véronique-Isabelle Forest
Michael P. Hier
Ji Wei Yang
Michael Tamilia
Richard J. Payne
author_sort Jennifer A. Silver
title BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
title_short BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
title_full BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
title_fullStr BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
title_full_unstemmed BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
title_sort braf v600e mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
publisher BMC
publishDate 2021
url https://doaj.org/article/69f36f0391804101aeee2d7d2f4dce8f
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