Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge

Abstract Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in treatment over the past several decades have significantly improved the outlook for this disease, most women who are diagnosed with estrogen receptor positive disease remain at risk of metastatic relapse fo...

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Autores principales:	Grace G. Bushnell, Abhijeet P. Deshmukh, Petra den Hollander, Ming Luo, Rama Soundararajan, Dongya Jia, Herbert Levine, Sendurai A. Mani, Max S. Wicha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/69f901f9c94041478c1dbc00eb262202
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spelling	oai:doaj.org-article:69f901f9c94041478c1dbc00eb2622022021-12-02T16:52:56ZBreast cancer dormancy: need for clinically relevant models to address current gaps in knowledge10.1038/s41523-021-00269-x2374-4677https://doaj.org/article/69f901f9c94041478c1dbc00eb2622022021-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00269-xhttps://doaj.org/toc/2374-4677Abstract Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in treatment over the past several decades have significantly improved the outlook for this disease, most women who are diagnosed with estrogen receptor positive disease remain at risk of metastatic relapse for the remainder of their life. The cellular source of late relapse in these patients is thought to be disseminated tumor cells that reactivate after a long period of dormancy. The biology of these dormant cells and their natural history over a patient’s lifetime is largely unclear. We posit that research on tumor dormancy has been significantly limited by the lack of clinically relevant models. This review will discuss existing dormancy models, gaps in biological understanding, and propose criteria for future models to enhance their clinical relevance.Grace G. BushnellAbhijeet P. DeshmukhPetra den HollanderMing LuoRama SoundararajanDongya JiaHerbert LevineSendurai A. ManiMax S. WichaNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Grace G. Bushnell Abhijeet P. Deshmukh Petra den Hollander Ming Luo Rama Soundararajan Dongya Jia Herbert Levine Sendurai A. Mani Max S. Wicha Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
description	Abstract Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in treatment over the past several decades have significantly improved the outlook for this disease, most women who are diagnosed with estrogen receptor positive disease remain at risk of metastatic relapse for the remainder of their life. The cellular source of late relapse in these patients is thought to be disseminated tumor cells that reactivate after a long period of dormancy. The biology of these dormant cells and their natural history over a patient’s lifetime is largely unclear. We posit that research on tumor dormancy has been significantly limited by the lack of clinically relevant models. This review will discuss existing dormancy models, gaps in biological understanding, and propose criteria for future models to enhance their clinical relevance.
format	article
author	Grace G. Bushnell Abhijeet P. Deshmukh Petra den Hollander Ming Luo Rama Soundararajan Dongya Jia Herbert Levine Sendurai A. Mani Max S. Wicha
author_facet	Grace G. Bushnell Abhijeet P. Deshmukh Petra den Hollander Ming Luo Rama Soundararajan Dongya Jia Herbert Levine Sendurai A. Mani Max S. Wicha
author_sort	Grace G. Bushnell
title	Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
title_short	Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
title_full	Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
title_fullStr	Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
title_full_unstemmed	Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
title_sort	breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69f901f9c94041478c1dbc00eb262202
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Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge

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