Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1...
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65 |
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oai:doaj.org-article:69f91741f8e94cd5827c2664a8377d652021-12-02T13:27:30ZInitiation of HIV neutralizing B cell lineages with sequential envelope immunizations10.1038/s41467-017-01336-32041-1723https://doaj.org/article/69f91741f8e94cd5827c2664a8377d652017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01336-3https://doaj.org/toc/2041-1723An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.Wilton B. WilliamsJinsong ZhangChuancang JiangNathan I. NicelyDaniela FeraKan LuoM. Anthony MoodyHua-Xin LiaoS. Munir AlamThomas B. KeplerAkshaya RameshKevin WieheJames A. HollandTodd BradleyNathan VandergriftKevin O. SaundersRobert ParksAndrew FoulgerShi-Mao XiaMattia BonsignoriDavid C. MontefioriMark LouderAmanda EatonSampa SantraRichard ScearceLaura SutherlandAmanda NewmanHilary Bouton-VervilleCindy BowmanHoward BomzeFeng GaoDawn J. MarshallJohn F. WhitesidesXiaoyan NieGarnett KelsoeSteven G. ReedChristopher B. FoxKim ClaryMarguerite KoutsoukosDavid FrancoJohn R. MascolaStephen C. HarrisonBarton F. HaynesLaurent VerkoczyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-20 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Wilton B. Williams Jinsong Zhang Chuancang Jiang Nathan I. Nicely Daniela Fera Kan Luo M. Anthony Moody Hua-Xin Liao S. Munir Alam Thomas B. Kepler Akshaya Ramesh Kevin Wiehe James A. Holland Todd Bradley Nathan Vandergrift Kevin O. Saunders Robert Parks Andrew Foulger Shi-Mao Xia Mattia Bonsignori David C. Montefiori Mark Louder Amanda Eaton Sampa Santra Richard Scearce Laura Sutherland Amanda Newman Hilary Bouton-Verville Cindy Bowman Howard Bomze Feng Gao Dawn J. Marshall John F. Whitesides Xiaoyan Nie Garnett Kelsoe Steven G. Reed Christopher B. Fox Kim Clary Marguerite Koutsoukos David Franco John R. Mascola Stephen C. Harrison Barton F. Haynes Laurent Verkoczy Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| description |
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual. |
| format |
article |
| author |
Wilton B. Williams Jinsong Zhang Chuancang Jiang Nathan I. Nicely Daniela Fera Kan Luo M. Anthony Moody Hua-Xin Liao S. Munir Alam Thomas B. Kepler Akshaya Ramesh Kevin Wiehe James A. Holland Todd Bradley Nathan Vandergrift Kevin O. Saunders Robert Parks Andrew Foulger Shi-Mao Xia Mattia Bonsignori David C. Montefiori Mark Louder Amanda Eaton Sampa Santra Richard Scearce Laura Sutherland Amanda Newman Hilary Bouton-Verville Cindy Bowman Howard Bomze Feng Gao Dawn J. Marshall John F. Whitesides Xiaoyan Nie Garnett Kelsoe Steven G. Reed Christopher B. Fox Kim Clary Marguerite Koutsoukos David Franco John R. Mascola Stephen C. Harrison Barton F. Haynes Laurent Verkoczy |
| author_facet |
Wilton B. Williams Jinsong Zhang Chuancang Jiang Nathan I. Nicely Daniela Fera Kan Luo M. Anthony Moody Hua-Xin Liao S. Munir Alam Thomas B. Kepler Akshaya Ramesh Kevin Wiehe James A. Holland Todd Bradley Nathan Vandergrift Kevin O. Saunders Robert Parks Andrew Foulger Shi-Mao Xia Mattia Bonsignori David C. Montefiori Mark Louder Amanda Eaton Sampa Santra Richard Scearce Laura Sutherland Amanda Newman Hilary Bouton-Verville Cindy Bowman Howard Bomze Feng Gao Dawn J. Marshall John F. Whitesides Xiaoyan Nie Garnett Kelsoe Steven G. Reed Christopher B. Fox Kim Clary Marguerite Koutsoukos David Franco John R. Mascola Stephen C. Harrison Barton F. Haynes Laurent Verkoczy |
| author_sort |
Wilton B. Williams |
| title |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| title_short |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| title_full |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| title_fullStr |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| title_full_unstemmed |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations |
| title_sort |
initiation of hiv neutralizing b cell lineages with sequential envelope immunizations |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65 |
| work_keys_str_mv |
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