Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor

BACKGROUND AND OBJECTIVE: Terbinfine a member of allylamines group is a new class of antimycotic agents that blocks sterol biosynthesis in the fungi through inhibition of sequlene epoxidase and with consequent sequalene accumulation due to a primarily fungicidal process. Terbinafine is very effectiv...

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Autores principales:	SM Rezvani, SAA Sefid Gar
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2006
Materias:	pityriasis versicolor fungal infection terbinafine clotrimazole Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/69fabfec4c054fdeb6d3c536d263f3c5
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spelling	oai:doaj.org-article:69fabfec4c054fdeb6d3c536d263f3c52021-11-10T09:12:42ZEfficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor1561-41072251-7170https://doaj.org/article/69fabfec4c054fdeb6d3c536d263f3c52006-04-01T00:00:00Zhttp://jbums.org/article-1-2556-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Terbinfine a member of allylamines group is a new class of antimycotic agents that blocks sterol biosynthesis in the fungi through inhibition of sequlene epoxidase and with consequent sequalene accumulation due to a primarily fungicidal process. Terbinafine is very effective on various fungi as an oral and topical antifungal agent. The aim of this study was to compare the antifungal efficacy of terbinafine 1% cream with clotrimazole 1% in patients with pityriasis versicolor.METHODS: This clinical trial study was performed on 50 patients (30 males and 20 females) with mean age of 20 years (aged between 15-55 years) who randomly treated with terbinafine and clotrimazole for 4 weeks. The efficacy of drug and improving process evaluated mycologically and clinically before starting the study and at the end of each week. A patient was considered mycologically cured when direct microscopy was negative and clinically cured when all clinical parameters were considered negative.FINDINGS: Negativizations of all clinical parameters were observed within 2 weeks in 60% of terbinofine and 35% clotrimazole recipients. At the end of four weeks, disappear of lesions were seen in 90% and 80%, respectively (p0.05). Both drug eruptions and intolerance in two treated groups were similar.CONCLUSION: Although the efficacy of the both drugs is similar, but considering the expense of therapy, clotrimazole is preferred regimen for therapy of tinea versicolor.SM Rezvani,SAA Sefid GarBabol University of Medical Sciencesarticlepityriasis versicolorfungal infectionterbinafineclotrimazoleMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 8, Iss 2, Pp 42-46 (2006)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	pityriasis versicolor fungal infection terbinafine clotrimazole Medicine R Medicine (General) R5-920
spellingShingle	pityriasis versicolor fungal infection terbinafine clotrimazole Medicine R Medicine (General) R5-920 SM Rezvani, SAA Sefid Gar Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
description	BACKGROUND AND OBJECTIVE: Terbinfine a member of allylamines group is a new class of antimycotic agents that blocks sterol biosynthesis in the fungi through inhibition of sequlene epoxidase and with consequent sequalene accumulation due to a primarily fungicidal process. Terbinafine is very effective on various fungi as an oral and topical antifungal agent. The aim of this study was to compare the antifungal efficacy of terbinafine 1% cream with clotrimazole 1% in patients with pityriasis versicolor.METHODS: This clinical trial study was performed on 50 patients (30 males and 20 females) with mean age of 20 years (aged between 15-55 years) who randomly treated with terbinafine and clotrimazole for 4 weeks. The efficacy of drug and improving process evaluated mycologically and clinically before starting the study and at the end of each week. A patient was considered mycologically cured when direct microscopy was negative and clinically cured when all clinical parameters were considered negative.FINDINGS: Negativizations of all clinical parameters were observed within 2 weeks in 60% of terbinofine and 35% clotrimazole recipients. At the end of four weeks, disappear of lesions were seen in 90% and 80%, respectively (p0.05). Both drug eruptions and intolerance in two treated groups were similar.CONCLUSION: Although the efficacy of the both drugs is similar, but considering the expense of therapy, clotrimazole is preferred regimen for therapy of tinea versicolor.
format	article
author	SM Rezvani, SAA Sefid Gar
author_facet	SM Rezvani, SAA Sefid Gar
author_sort	SM Rezvani,
title	Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
title_short	Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
title_full	Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
title_fullStr	Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
title_full_unstemmed	Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
title_sort	efficacy of terbinafine 1% cream versus clotrimazole 1% cream in the treatment of pityriasis versicolor
publisher	Babol University of Medical Sciences
publishDate	2006
url	https://doaj.org/article/69fabfec4c054fdeb6d3c536d263f3c5
work_keys_str_mv	AT smrezvani efficacyofterbinafine1creamversusclotrimazole1creaminthetreatmentofpityriasisversicolor AT saasefidgar efficacyofterbinafine1creamversusclotrimazole1creaminthetreatmentofpityriasisversicolor
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Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor

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