Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator

Abstract The cost of testing can be a substantial contributor to hepatitis C virus (HCV) elimination program costs in many low- and middle-income countries such as Georgia, resulting in the need for innovative and cost-effective strategies for testing. Our objective was to investigate the most cost-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Madeline Adee, Yueran Zhuo, Huaiyang Zhong, Tiannan Zhan, Rakesh Aggarwal, Sonjelle Shilton, Jagpreet Chhatwal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69fbfe6975ac4a8b9a931ec72a2b0e13
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:69fbfe6975ac4a8b9a931ec72a2b0e13
record_format	dspace
spelling	oai:doaj.org-article:69fbfe6975ac4a8b9a931ec72a2b0e132021-11-08T10:47:37ZAssessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator10.1038/s41598-021-00362-y2045-2322https://doaj.org/article/69fbfe6975ac4a8b9a931ec72a2b0e132021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00362-yhttps://doaj.org/toc/2045-2322Abstract The cost of testing can be a substantial contributor to hepatitis C virus (HCV) elimination program costs in many low- and middle-income countries such as Georgia, resulting in the need for innovative and cost-effective strategies for testing. Our objective was to investigate the most cost-effective testing pathways for scaling-up HCV testing in Georgia. We developed a Markov-based model with a lifetime horizon that simulates the natural history of HCV, and the cost of detection and treatment of HCV. We then created an interactive online tool that uses results from the Markov-based model to evaluate the cost-effectiveness of different HCV testing pathways. We compared the current standard-of-care (SoC) testing pathway and four innovative testing pathways for Georgia. The SoC testing was cost-saving compared to no testing, but all four new HCV testing pathways further increased QALYs and decreased costs. The pathway with the highest patient follow-up, due to on-site testing, resulted in the highest discounted QALYs (123 QALY more than the SoC) and lowest costs ($127,052 less than the SoC) per 10,000 persons screened. The current testing algorithm in Georgia can be replaced with a new pathway that is more effective while being cost-saving.Madeline AdeeYueran ZhuoHuaiyang ZhongTiannan ZhanRakesh AggarwalSonjelle ShiltonJagpreet ChhatwalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madeline Adee Yueran Zhuo Huaiyang Zhong Tiannan Zhan Rakesh Aggarwal Sonjelle Shilton Jagpreet Chhatwal Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
description	Abstract The cost of testing can be a substantial contributor to hepatitis C virus (HCV) elimination program costs in many low- and middle-income countries such as Georgia, resulting in the need for innovative and cost-effective strategies for testing. Our objective was to investigate the most cost-effective testing pathways for scaling-up HCV testing in Georgia. We developed a Markov-based model with a lifetime horizon that simulates the natural history of HCV, and the cost of detection and treatment of HCV. We then created an interactive online tool that uses results from the Markov-based model to evaluate the cost-effectiveness of different HCV testing pathways. We compared the current standard-of-care (SoC) testing pathway and four innovative testing pathways for Georgia. The SoC testing was cost-saving compared to no testing, but all four new HCV testing pathways further increased QALYs and decreased costs. The pathway with the highest patient follow-up, due to on-site testing, resulted in the highest discounted QALYs (123 QALY more than the SoC) and lowest costs ($127,052 less than the SoC) per 10,000 persons screened. The current testing algorithm in Georgia can be replaced with a new pathway that is more effective while being cost-saving.
format	article
author	Madeline Adee Yueran Zhuo Huaiyang Zhong Tiannan Zhan Rakesh Aggarwal Sonjelle Shilton Jagpreet Chhatwal
author_facet	Madeline Adee Yueran Zhuo Huaiyang Zhong Tiannan Zhan Rakesh Aggarwal Sonjelle Shilton Jagpreet Chhatwal
author_sort	Madeline Adee
title	Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
title_short	Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
title_full	Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
title_fullStr	Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
title_full_unstemmed	Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
title_sort	assessing cost-effectiveness of hepatitis c testing pathways in georgia using the hep c testing calculator
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69fbfe6975ac4a8b9a931ec72a2b0e13
work_keys_str_mv	AT madelineadee assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT yueranzhuo assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT huaiyangzhong assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT tiannanzhan assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT rakeshaggarwal assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT sonjelleshilton assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator AT jagpreetchhatwal assessingcosteffectivenessofhepatitisctestingpathwaysingeorgiausingthehepctestingcalculator
_version_	1718442624610729984

Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator

Ejemplares similares