Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model

Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model

Fragile X syndrome (FXS) is a leading cause of autism and neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, the authors show that neurons from Fmr1 knockout mice have increased levels of ADCY1 protein, producing abnormal ERK1/2 signalling, dysregulated protein s...

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Autores principales: Ferzin Sethna, Wei Feng, Qi Ding, Alfred J. Robison, Yue Feng, Hongbing Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6a001a68f0bf44dba2df56acb2fb1626
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spelling oai:doaj.org-article:6a001a68f0bf44dba2df56acb2fb16262021-12-02T17:06:22ZEnhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model10.1038/ncomms143592041-1723https://doaj.org/article/6a001a68f0bf44dba2df56acb2fb16262017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14359https://doaj.org/toc/2041-1723Fragile X syndrome (FXS) is a leading cause of autism and neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, the authors show that neurons from Fmr1 knockout mice have increased levels of ADCY1 protein, producing abnormal ERK1/2 signalling, dysregulated protein synthesis and behavioural symptoms associated with FXS.Ferzin SethnaWei FengQi DingAlfred J. RobisonYue FengHongbing WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ferzin Sethna
Wei Feng
Qi Ding
Alfred J. Robison
Yue Feng
Hongbing Wang
Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
description Fragile X syndrome (FXS) is a leading cause of autism and neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, the authors show that neurons from Fmr1 knockout mice have increased levels of ADCY1 protein, producing abnormal ERK1/2 signalling, dysregulated protein synthesis and behavioural symptoms associated with FXS.
format article
author Ferzin Sethna
Wei Feng
Qi Ding
Alfred J. Robison
Yue Feng
Hongbing Wang
author_facet Ferzin Sethna
Wei Feng
Qi Ding
Alfred J. Robison
Yue Feng
Hongbing Wang
author_sort Ferzin Sethna
title Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
title_short Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
title_full Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
title_fullStr Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
title_full_unstemmed Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
title_sort enhanced expression of adcy1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6a001a68f0bf44dba2df56acb2fb1626
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AT hongbingwang enhancedexpressionofadcy1underliesaberrantneuronalsignallingandbehaviourinasyndromicautismmodel
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