Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle

Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle

Hui Song, Man Wei, Nan Zhang, He Li, Xiaochuan Tan, Yujia Zhang, Wensheng Zheng Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China...

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Autores principales: Song H, Wei M, Zhang N, Li H, Tan XC, Zhang YJ, Zheng WS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Blood–brain barrier
borneol
solid lipid nanoparticle
targeting function
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/6a040b4fd425471fab4224642af92c84
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spelling oai:doaj.org-article:6a040b4fd425471fab4224642af92c842021-12-02T01:27:50ZEnhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle1178-2013https://doaj.org/article/6a040b4fd425471fab4224642af92c842018-03-01T00:00:00Zhttps://www.dovepress.com/enhanced-permeability-of-blood-brain-barrier-and-targeting-function-of-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hui Song, Man Wei, Nan Zhang, He Li, Xiaochuan Tan, Yujia Zhang, Wensheng Zheng Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Introduction: The incidence of central nervous system disease has increased in recent years. However, the transportation of drug is restricted by the blood–brain barrier, contributing to the poor therapeutic effect in the brain. Therefore, the development of a new brain-targeting drug delivery system has become the hotspot of pharmacy. Materials and methods: Borneol, a simple bicyclic monoterpene extracted from Dryobalanops aromatica, can direct drugs to the upper body parts according to the theory of traditional Chinese medicine. Dioleoyl phosphoethanolamine (DOPE) was chemically modified by borneol as one of the lipid materials of solid lipid nanoparticle (SLN) in the present study. Results: The borneol-modified chemically solid lipid nanoparticle (BO-SLN/CM), borneol-modified physically solid lipid nanoparticle (BO-SLN/PM), and SLN have similar diameter (of about 87 nm) and morphological characteristics. However, BO-SLN/CM has a lower cytotoxicity, higher cell uptake, and better blood–brain barrier permeability compared with BO-SLN/PM and SLN. BO-SLN/CM has a remarkable targeting function to the brain, while BO-SLN/PM and SLNs are concentrated at the lung. Conclusion: The present study provides an excellent drug delivery carrier, BO-SLN/CM, having the application potential of targeting to the brain and permeating to the blood–brain barrier. Keywords: blood–brain barrier, solid lipid nanoparticle, phospholipid modification, BBB model in vitro, body distributionSong HWei MZhang NLi HTan XCZhang YJZheng WSDove Medical PressarticleBlood–brain barrierborneolsolid lipid nanoparticletargeting functionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1869-1879 (2018)
institution DOAJ
collection DOAJ
language EN
topic Blood–brain barrier
borneol
solid lipid nanoparticle
targeting function
Medicine (General)
R5-920
spellingShingle Blood–brain barrier
borneol
solid lipid nanoparticle
targeting function
Medicine (General)
R5-920
Song H
Wei M
Zhang N
Li H
Tan XC
Zhang YJ
Zheng WS
Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
description Hui Song, Man Wei, Nan Zhang, He Li, Xiaochuan Tan, Yujia Zhang, Wensheng Zheng Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Introduction: The incidence of central nervous system disease has increased in recent years. However, the transportation of drug is restricted by the blood–brain barrier, contributing to the poor therapeutic effect in the brain. Therefore, the development of a new brain-targeting drug delivery system has become the hotspot of pharmacy. Materials and methods: Borneol, a simple bicyclic monoterpene extracted from Dryobalanops aromatica, can direct drugs to the upper body parts according to the theory of traditional Chinese medicine. Dioleoyl phosphoethanolamine (DOPE) was chemically modified by borneol as one of the lipid materials of solid lipid nanoparticle (SLN) in the present study. Results: The borneol-modified chemically solid lipid nanoparticle (BO-SLN/CM), borneol-modified physically solid lipid nanoparticle (BO-SLN/PM), and SLN have similar diameter (of about 87 nm) and morphological characteristics. However, BO-SLN/CM has a lower cytotoxicity, higher cell uptake, and better blood–brain barrier permeability compared with BO-SLN/PM and SLN. BO-SLN/CM has a remarkable targeting function to the brain, while BO-SLN/PM and SLNs are concentrated at the lung. Conclusion: The present study provides an excellent drug delivery carrier, BO-SLN/CM, having the application potential of targeting to the brain and permeating to the blood–brain barrier. Keywords: blood–brain barrier, solid lipid nanoparticle, phospholipid modification, BBB model in vitro, body distribution
format article
author Song H
Wei M
Zhang N
Li H
Tan XC
Zhang YJ
Zheng WS
author_facet Song H
Wei M
Zhang N
Li H
Tan XC
Zhang YJ
Zheng WS
author_sort Song H
title Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
title_short Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
title_full Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
title_fullStr Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
title_full_unstemmed Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
title_sort enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/6a040b4fd425471fab4224642af92c84
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AT weim enhancedpermeabilityofbloodndashbrainbarrierandtargetingfunctionofbrainviaborneolmodifiedchemicallysolidlipidnanoparticle
AT zhangn enhancedpermeabilityofbloodndashbrainbarrierandtargetingfunctionofbrainviaborneolmodifiedchemicallysolidlipidnanoparticle
AT lih enhancedpermeabilityofbloodndashbrainbarrierandtargetingfunctionofbrainviaborneolmodifiedchemicallysolidlipidnanoparticle
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AT zhangyj enhancedpermeabilityofbloodndashbrainbarrierandtargetingfunctionofbrainviaborneolmodifiedchemicallysolidlipidnanoparticle
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