Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia

Abstract Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cog...

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Autores principales:	Xiuru Su, Limin Qiao, Qing Liu, Yujie Shang, Xiaoni Guan, Meihong Xiu, Xiangyang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a05cba8e94c4e2089138ecc119d8f9e
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spelling	oai:doaj.org-article:6a05cba8e94c4e2089138ecc119d8f9e2021-12-02T17:13:16ZGenetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia10.1038/s41598-021-99510-72045-2322https://doaj.org/article/6a05cba8e94c4e2089138ecc119d8f9e2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99510-7https://doaj.org/toc/2045-2322Abstract Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naïve first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients.Xiuru SuLimin QiaoQing LiuYujie ShangXiaoni GuanMeihong XiuXiangyang ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiuru Su Limin Qiao Qing Liu Yujie Shang Xiaoni Guan Meihong Xiu Xiangyang Zhang Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
description	Abstract Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naïve first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients.
format	article
author	Xiuru Su Limin Qiao Qing Liu Yujie Shang Xiaoni Guan Meihong Xiu Xiangyang Zhang
author_facet	Xiuru Su Limin Qiao Qing Liu Yujie Shang Xiaoni Guan Meihong Xiu Xiangyang Zhang
author_sort	Xiuru Su
title	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
title_short	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
title_full	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
title_fullStr	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
title_full_unstemmed	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
title_sort	genetic polymorphisms of bdnf on cognitive functions in drug-naive first episode patients with schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a05cba8e94c4e2089138ecc119d8f9e
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Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia

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