IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES

Abstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for...

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Auteurs principaux:	A. A. Rumbesht, A. E. Matsionis, A. A. Dyuzhikov, I. V. Sarvilina
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	infectious endocarditis clinical proteomics mass-spectrometry Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/6a07bf747908444fb93ca65cea899e8c
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id	oai:doaj.org-article:6a07bf747908444fb93ca65cea899e8c
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spelling	oai:doaj.org-article:6a07bf747908444fb93ca65cea899e8c2021-11-18T08:03:37ZIMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES1563-06252313-741X10.15789/1563-0625-2008-1-27-34https://doaj.org/article/6a07bf747908444fb93ca65cea899e8c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/75https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for clinical proteomics. Ninety-nine patients with infectious endocarditis of native heart valves were included into the study. All the patients were examined according to hospital assessment protocol, including clinical, laboratory and instrumental methods of evaluation. Separation and identification of proteins of microorganisms in blood and materials taken at surgery, detection of proteins related to functioning of immune system, were carried out using new methods of clinical proteomics. We have revealed same proteins, that are specific of pathogens causing infectious endocarditis, that thus representing immunogenic determinants and defining a systemic immune response in the patients.A. A. RumbeshtA. E. MatsionisA. A. DyuzhikovI. V. SarvilinaSPb RAACIarticleinfectious endocarditisclinical proteomicsmass-spectrometryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 27-34 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	infectious endocarditis clinical proteomics mass-spectrometry Immunologic diseases. Allergy RC581-607
spellingShingle	infectious endocarditis clinical proteomics mass-spectrometry Immunologic diseases. Allergy RC581-607 A. A. Rumbesht A. E. Matsionis A. A. Dyuzhikov I. V. Sarvilina IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
description	Abstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for clinical proteomics. Ninety-nine patients with infectious endocarditis of native heart valves were included into the study. All the patients were examined according to hospital assessment protocol, including clinical, laboratory and instrumental methods of evaluation. Separation and identification of proteins of microorganisms in blood and materials taken at surgery, detection of proteins related to functioning of immune system, were carried out using new methods of clinical proteomics. We have revealed same proteins, that are specific of pathogens causing infectious endocarditis, that thus representing immunogenic determinants and defining a systemic immune response in the patients.
format	article
author	A. A. Rumbesht A. E. Matsionis A. A. Dyuzhikov I. V. Sarvilina
author_facet	A. A. Rumbesht A. E. Matsionis A. A. Dyuzhikov I. V. Sarvilina
author_sort	A. A. Rumbesht
title	IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
title_short	IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
title_full	IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
title_fullStr	IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
title_full_unstemmed	IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
title_sort	immunoproteomics of infectious endocarditis of native heartvalves
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6a07bf747908444fb93ca65cea899e8c
work_keys_str_mv	AT aarumbesht immunoproteomicsofinfectiousendocarditisofnativeheartvalves AT aematsionis immunoproteomicsofinfectiousendocarditisofnativeheartvalves AT aadyuzhikov immunoproteomicsofinfectiousendocarditisofnativeheartvalves AT ivsarvilina immunoproteomicsofinfectiousendocarditisofnativeheartvalves
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IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES

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