Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation

Abstract BK polyomavirus (BKPyV) and cytomegalovirus (CMV) are the main viral pathogens affecting the graft and recipient outcome after allogenic kidney transplantation. It has recently been found that infection with both viruses has a greater impact on kidney graft function than a single infection....

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Autores principales:	Ulrich Jehn, Katharina Schütte-Nütgen, Joachim Bautz, Hermann Pavenstädt, Barbara Suwelack, Gerold Thölking, Stefan Reuter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a07daa354b246c3870e6f8a64e3e60a
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spelling	oai:doaj.org-article:6a07daa354b246c3870e6f8a64e3e60a2021-12-02T15:12:47ZClinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation10.1038/s41598-020-79799-62045-2322https://doaj.org/article/6a07daa354b246c3870e6f8a64e3e60a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79799-6https://doaj.org/toc/2045-2322Abstract BK polyomavirus (BKPyV) and cytomegalovirus (CMV) are the main viral pathogens affecting the graft and recipient outcome after allogenic kidney transplantation. It has recently been found that infection with both viruses has a greater impact on kidney graft function than a single infection. We retrospectively analyzed a cohort of 723 recipients who received kidney transplantation between 2007 and 2015 after living and postmortal donation for differences in risk and outcome parameters regarding BKPyV (DNAemia) and CMV (CMV DNAemia) co-infection compared to sole viremias and to patients without viremia. Of all kidney allograft recipients in our cohort, 8.2% developed co-infection with BKPyV DNAemia and CMV DNAemia, 15.1% showed BKPyV viremia alone and 25.2% sole CMV DNAemia. Acute rejection was closely linked with co-infection (multivariable analysis, p = 0.001). Despite the fact that the estimated glomerular filtration rate of patients with co-infection was noticeably reduced compared to patients with BKV or CMV infection alone, transplant survival and patient survival were not significantly reduced. Co-infection with BKPyV and CMV in kidney transplanted patients is significantly associated with inferior allograft function. Since co-infection is strongly associated with acute rejection, co-infected individuals should be considered a risk collective.Ulrich JehnKatharina Schütte-NütgenJoachim BautzHermann PavenstädtBarbara SuwelackGerold ThölkingStefan ReuterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ulrich Jehn Katharina Schütte-Nütgen Joachim Bautz Hermann Pavenstädt Barbara Suwelack Gerold Thölking Stefan Reuter Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
description	Abstract BK polyomavirus (BKPyV) and cytomegalovirus (CMV) are the main viral pathogens affecting the graft and recipient outcome after allogenic kidney transplantation. It has recently been found that infection with both viruses has a greater impact on kidney graft function than a single infection. We retrospectively analyzed a cohort of 723 recipients who received kidney transplantation between 2007 and 2015 after living and postmortal donation for differences in risk and outcome parameters regarding BKPyV (DNAemia) and CMV (CMV DNAemia) co-infection compared to sole viremias and to patients without viremia. Of all kidney allograft recipients in our cohort, 8.2% developed co-infection with BKPyV DNAemia and CMV DNAemia, 15.1% showed BKPyV viremia alone and 25.2% sole CMV DNAemia. Acute rejection was closely linked with co-infection (multivariable analysis, p = 0.001). Despite the fact that the estimated glomerular filtration rate of patients with co-infection was noticeably reduced compared to patients with BKV or CMV infection alone, transplant survival and patient survival were not significantly reduced. Co-infection with BKPyV and CMV in kidney transplanted patients is significantly associated with inferior allograft function. Since co-infection is strongly associated with acute rejection, co-infected individuals should be considered a risk collective.
format	article
author	Ulrich Jehn Katharina Schütte-Nütgen Joachim Bautz Hermann Pavenstädt Barbara Suwelack Gerold Thölking Stefan Reuter
author_facet	Ulrich Jehn Katharina Schütte-Nütgen Joachim Bautz Hermann Pavenstädt Barbara Suwelack Gerold Thölking Stefan Reuter
author_sort	Ulrich Jehn
title	Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
title_short	Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
title_full	Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
title_fullStr	Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
title_full_unstemmed	Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
title_sort	clinical features of bk-polyomavirus and cytomegalovirus co-infection after kidney transplantation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6a07daa354b246c3870e6f8a64e3e60a
work_keys_str_mv	AT ulrichjehn clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT katharinaschuttenutgen clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT joachimbautz clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT hermannpavenstadt clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT barbarasuwelack clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT geroldtholking clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation AT stefanreuter clinicalfeaturesofbkpolyomavirusandcytomegaloviruscoinfectionafterkidneytransplantation
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Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation

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