Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period

The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients. Our aim was to compare the demographic features, clinical courses and outcomes of confirmed and probable coronavirus disease 2019 (COVID-19...

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Autores principales:	Fatma İrem Yeşiler, Mesher Çapras, Emre Kandemir, Helin Şahintürk, Ender Gedik, Pınar Zeyneloğlu
Formato:	article
Lenguaje:	EN
Publicado:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Materias:	COVID-19 SARS-CoV-2 confirmed probable intensive care unit normalization period Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6a09f428f0fe4d0fa914aa35c69f1ad8
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spelling	oai:doaj.org-article:6a09f428f0fe4d0fa914aa35c69f1ad82021-11-23T17:18:53ZComparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period10.17305/bjbms.2021.66571512-86011840-4812https://doaj.org/article/6a09f428f0fe4d0fa914aa35c69f1ad82021-11-01T00:00:00Zhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/6657https://doaj.org/toc/1512-8601https://doaj.org/toc/1840-4812 The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients. Our aim was to compare the demographic features, clinical courses and outcomes of confirmed and probable coronavirus disease 2019 (COVID-19) patients admitted to our intensive care unit (ICU) during the normalization period. Critically ill 128 COVID-19 patients between June 1 - December 2, 2020 were analyzed retrospectively. The mean age was 69.7±15.5y (61.7% male). Sixty-one patients (47.7%) were confirmed. Dyspnea (75.0%) was the most common symptom and hypertension (71.1%) was the most common comorbidity. The mean Acute Physiology and Chronic Health Evaluation System (APACHE II) score; Glasgow Coma Score (GCS); Sequential Organ Failure Assessment (SOFA) scores on ICU admission were 17.4 ± 8.2, 12.3 ± 3.9 and 5.9 ± 3.4, respectively. 101 patients (78.1%) received low flow oxygen, 48 had high flow oxygen therapy (37.5%) and 59 (46.1%) had invasive mechanical ventilation. 53 patients (41.4%) had vasopressor therapy and 30 (23.4%) patients had renal replacement therapy (RRT) due to acute kidney injury (AKI). Confirmed patients were more tachypneic (p=0.005) and more hypoxemic than probable patients (p<0.001). Acute respiratory distress syndrome (ARDS) and AKI were more common in confirmed patients than probable (both p<0.001). Confirmed patients had higher values of hemoglobin, C- reactive protein, fibrinogen, D-dimer than probables (respectively, p=0.028, 0.006, 0.000, 0.019). The overall mortality was higher in confirmed patients (p=0.209, 52.6% vs 47.4%). Complications are more common among confirmed COVID-19 patients admitted to ICU. The mortality rate of confirmed COVID-19 patients admitted to the ICU was found to be higher than probable patients. Mortality of confirmed cases were higher than prediction of APACHE-II scoring system. Fatma İrem YeşilerMesher ÇaprasEmre KandemirHelin ŞahintürkEnder GedikPınar ZeyneloğluAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaarticleCOVID-19SARS-CoV-2confirmedprobableintensive care unitnormalization periodMedicine (General)R5-920ENBosnian Journal of Basic Medical Sciences (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 confirmed probable intensive care unit normalization period Medicine (General) R5-920
spellingShingle	COVID-19 SARS-CoV-2 confirmed probable intensive care unit normalization period Medicine (General) R5-920 Fatma İrem Yeşiler Mesher Çapras Emre Kandemir Helin Şahintürk Ender Gedik Pınar Zeyneloğlu Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
description	The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients. Our aim was to compare the demographic features, clinical courses and outcomes of confirmed and probable coronavirus disease 2019 (COVID-19) patients admitted to our intensive care unit (ICU) during the normalization period. Critically ill 128 COVID-19 patients between June 1 - December 2, 2020 were analyzed retrospectively. The mean age was 69.7±15.5y (61.7% male). Sixty-one patients (47.7%) were confirmed. Dyspnea (75.0%) was the most common symptom and hypertension (71.1%) was the most common comorbidity. The mean Acute Physiology and Chronic Health Evaluation System (APACHE II) score; Glasgow Coma Score (GCS); Sequential Organ Failure Assessment (SOFA) scores on ICU admission were 17.4 ± 8.2, 12.3 ± 3.9 and 5.9 ± 3.4, respectively. 101 patients (78.1%) received low flow oxygen, 48 had high flow oxygen therapy (37.5%) and 59 (46.1%) had invasive mechanical ventilation. 53 patients (41.4%) had vasopressor therapy and 30 (23.4%) patients had renal replacement therapy (RRT) due to acute kidney injury (AKI). Confirmed patients were more tachypneic (p=0.005) and more hypoxemic than probable patients (p<0.001). Acute respiratory distress syndrome (ARDS) and AKI were more common in confirmed patients than probable (both p<0.001). Confirmed patients had higher values of hemoglobin, C- reactive protein, fibrinogen, D-dimer than probables (respectively, p=0.028, 0.006, 0.000, 0.019). The overall mortality was higher in confirmed patients (p=0.209, 52.6% vs 47.4%). Complications are more common among confirmed COVID-19 patients admitted to ICU. The mortality rate of confirmed COVID-19 patients admitted to the ICU was found to be higher than probable patients. Mortality of confirmed cases were higher than prediction of APACHE-II scoring system.
format	article
author	Fatma İrem Yeşiler Mesher Çapras Emre Kandemir Helin Şahintürk Ender Gedik Pınar Zeyneloğlu
author_facet	Fatma İrem Yeşiler Mesher Çapras Emre Kandemir Helin Şahintürk Ender Gedik Pınar Zeyneloğlu
author_sort	Fatma İrem Yeşiler
title	Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
title_short	Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
title_full	Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
title_fullStr	Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
title_full_unstemmed	Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period
title_sort	comparison of confirmed and probable covid-19 patients in the intensive care unit during the normalization period
publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
publishDate	2021
url	https://doaj.org/article/6a09f428f0fe4d0fa914aa35c69f1ad8
work_keys_str_mv	AT fatmairemyesiler comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod AT meshercapras comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod AT emrekandemir comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod AT helinsahinturk comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod AT endergedik comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod AT pınarzeyneloglu comparisonofconfirmedandprobablecovid19patientsintheintensivecareunitduringthenormalizationperiod
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Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period

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