Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery

Andreas A Mueller,1,2 Nadeem Kalak,3 Katja Schwenzer-Zimmerer,1,2 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Craniomaxillofacial Surgery, University of Basel and University Hospital of Basel, Basel, Switzerland; 2Hightech Research Center of Craniomaxillofacial Surgery, University of Basel, Basel,...

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Autores principales:	Mueller AA, Kalak N, Schwenzer-Zimmerer K, Holsboer-Trachsler E, Br, S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6a0ac0bf17c9473c9f7cbcc47e13b098
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spelling	oai:doaj.org-article:6a0ac0bf17c9473c9f7cbcc47e13b0982021-12-02T03:38:24ZCortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery1178-2021https://doaj.org/article/6a0ac0bf17c9473c9f7cbcc47e13b0982014-10-01T00:00:00Zhttp://www.dovepress.com/cortisol-levels-and-sleep-patterns-in-infants-with-orofacial-clefts-un-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Andreas A Mueller,1,2 Nadeem Kalak,3 Katja Schwenzer-Zimmerer,1,2 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Craniomaxillofacial Surgery, University of Basel and University Hospital of Basel, Basel, Switzerland; 2Hightech Research Center of Craniomaxillofacial Surgery, University of Basel, Basel, Switzerland; 3Psychiatric Clinics of the University of Basel, Center for Affective, Stress, and Sleep Disorders, Basel, Switzerland; 4Department of Sport and Health Science, Division of Sport Science, University of Basel, Basel, Switzerland Background: Traumatic events during early infancy might damage infants’ psychobiological functioning, such as sleep and cortisol secretion. Infants born with orofacial clefts (OFCs) undergo functional, anatomical, and aesthetic surgery. The aim of the present study was to determine whether infants with OFC and undergoing OFC surgery show deteriorated sleep and cortisol secretion compared with healthy controls and with their presurgery status.Methods: A total of 27 infants with OFC (mean age: 22 weeks) and 30 healthy controls (mean age: 23 weeks) took part in the study. For infants with OFC, sleep actigraphy was performed and saliva cortisol was analyzed 5 days before, during, and 5 days after surgery. For controls, sleep and saliva cortisol were assessed similarly, except for the period taken up with surgery.Results: Compared with healthy controls, infants with OFC undergoing OFC surgery did not differ in sleep and cortisol secretion. Their sleep and cortisol secretion did deteriorate during the perisurgical period but recovered 5 days postsurgery. Conclusion: In infants with OFC undergoing corrective surgery, the pattern of results for sleep and cortisol suggests that OFC surgery does not seem to constitute a traumatic event with long-term consequences. Keywords: cortisol, sleep, orofacial cleft, surgery, infantsMueller AAKalak NSchwenzer-Zimmerer KHolsboer-Trachsler EBrSDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1965-1972 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mueller AA Kalak N Schwenzer-Zimmerer K Holsboer-Trachsler E Br S Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
description	Andreas A Mueller,1,2 Nadeem Kalak,3 Katja Schwenzer-Zimmerer,1,2 Edith Holsboer-Trachsler,3 Serge Brand3,4 1Craniomaxillofacial Surgery, University of Basel and University Hospital of Basel, Basel, Switzerland; 2Hightech Research Center of Craniomaxillofacial Surgery, University of Basel, Basel, Switzerland; 3Psychiatric Clinics of the University of Basel, Center for Affective, Stress, and Sleep Disorders, Basel, Switzerland; 4Department of Sport and Health Science, Division of Sport Science, University of Basel, Basel, Switzerland Background: Traumatic events during early infancy might damage infants’ psychobiological functioning, such as sleep and cortisol secretion. Infants born with orofacial clefts (OFCs) undergo functional, anatomical, and aesthetic surgery. The aim of the present study was to determine whether infants with OFC and undergoing OFC surgery show deteriorated sleep and cortisol secretion compared with healthy controls and with their presurgery status.Methods: A total of 27 infants with OFC (mean age: 22 weeks) and 30 healthy controls (mean age: 23 weeks) took part in the study. For infants with OFC, sleep actigraphy was performed and saliva cortisol was analyzed 5 days before, during, and 5 days after surgery. For controls, sleep and saliva cortisol were assessed similarly, except for the period taken up with surgery.Results: Compared with healthy controls, infants with OFC undergoing OFC surgery did not differ in sleep and cortisol secretion. Their sleep and cortisol secretion did deteriorate during the perisurgical period but recovered 5 days postsurgery. Conclusion: In infants with OFC undergoing corrective surgery, the pattern of results for sleep and cortisol suggests that OFC surgery does not seem to constitute a traumatic event with long-term consequences. Keywords: cortisol, sleep, orofacial cleft, surgery, infants
format	article
author	Mueller AA Kalak N Schwenzer-Zimmerer K Holsboer-Trachsler E Br S
author_facet	Mueller AA Kalak N Schwenzer-Zimmerer K Holsboer-Trachsler E Br S
author_sort	Mueller AA
title	Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
title_short	Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
title_full	Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
title_fullStr	Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
title_full_unstemmed	Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
title_sort	cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/6a0ac0bf17c9473c9f7cbcc47e13b098
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_version_	1718401668259774464

Cortisol levels and sleep patterns in infants with orofacial clefts undergoing surgery

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