Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer

Abstract Shear wave elastography (SWE) is a technique to non-invasively and quantitatively evaluate tissue stiffness. We aimed to investigate whether we can differentiate pancreatic cancer (PC) from normal pancreatic parenchyma (NPP) by SWE using transabdominal ultrasound. We investigated a total of...

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Autores principales:	Masakatsu Yoshikawa, Takuya Ishikawa, Eizaburo Ohno, Tadashi Iida, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Fumie Kinoshita, Hiroki Kawashima, Mitsuhiro Fujishiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a11076592094e3cb0288191eda7fc46
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spelling	oai:doaj.org-article:6a11076592094e3cb0288191eda7fc462021-12-02T14:23:18ZVariability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer10.1038/s41598-021-86979-52045-2322https://doaj.org/article/6a11076592094e3cb0288191eda7fc462021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86979-5https://doaj.org/toc/2045-2322Abstract Shear wave elastography (SWE) is a technique to non-invasively and quantitatively evaluate tissue stiffness. We aimed to investigate whether we can differentiate pancreatic cancer (PC) from normal pancreatic parenchyma (NPP) by SWE using transabdominal ultrasound. We investigated a total of 106 patients (84 with NPP and 22 with PC) whose pancreatic elastic modulus was measured by two-dimensional SWE (2D-SWE). Intra-rater reliability in this study was examined, and three measurements were sufficiently reliable. There were no differences between the two groups in factors that could affect SWE measurements. The median value of the elastic modulus was 5.70 kPa in the PC patients and 5.66 kPa in the NPP group, which was not significantly different (P = 0.785). On the contrary, the range was 8.64 kPa and 4.72 kPa, with a significantly greater range in the PC patients (P = 0.001). In conclusion, the median elastic modulus measured by 2D-SWE was not significantly different between PC and NPP, and evaluating the obtained elastic modulus itself is not useful in differentiation. However, the variability was significantly greater in PC than in NPP. Evaluating the range of elasticities will provide additional information in SWE, which may be useful in the diagnosis of PC.Masakatsu YoshikawaTakuya IshikawaEizaburo OhnoTadashi IidaKazuhiro FurukawaMasanao NakamuraTakashi HondaMasatoshi IshigamiFumie KinoshitaHiroki KawashimaMitsuhiro FujishiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masakatsu Yoshikawa Takuya Ishikawa Eizaburo Ohno Tadashi Iida Kazuhiro Furukawa Masanao Nakamura Takashi Honda Masatoshi Ishigami Fumie Kinoshita Hiroki Kawashima Mitsuhiro Fujishiro Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
description	Abstract Shear wave elastography (SWE) is a technique to non-invasively and quantitatively evaluate tissue stiffness. We aimed to investigate whether we can differentiate pancreatic cancer (PC) from normal pancreatic parenchyma (NPP) by SWE using transabdominal ultrasound. We investigated a total of 106 patients (84 with NPP and 22 with PC) whose pancreatic elastic modulus was measured by two-dimensional SWE (2D-SWE). Intra-rater reliability in this study was examined, and three measurements were sufficiently reliable. There were no differences between the two groups in factors that could affect SWE measurements. The median value of the elastic modulus was 5.70 kPa in the PC patients and 5.66 kPa in the NPP group, which was not significantly different (P = 0.785). On the contrary, the range was 8.64 kPa and 4.72 kPa, with a significantly greater range in the PC patients (P = 0.001). In conclusion, the median elastic modulus measured by 2D-SWE was not significantly different between PC and NPP, and evaluating the obtained elastic modulus itself is not useful in differentiation. However, the variability was significantly greater in PC than in NPP. Evaluating the range of elasticities will provide additional information in SWE, which may be useful in the diagnosis of PC.
format	article
author	Masakatsu Yoshikawa Takuya Ishikawa Eizaburo Ohno Tadashi Iida Kazuhiro Furukawa Masanao Nakamura Takashi Honda Masatoshi Ishigami Fumie Kinoshita Hiroki Kawashima Mitsuhiro Fujishiro
author_facet	Masakatsu Yoshikawa Takuya Ishikawa Eizaburo Ohno Tadashi Iida Kazuhiro Furukawa Masanao Nakamura Takashi Honda Masatoshi Ishigami Fumie Kinoshita Hiroki Kawashima Mitsuhiro Fujishiro
author_sort	Masakatsu Yoshikawa
title	Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
title_short	Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
title_full	Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
title_fullStr	Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
title_full_unstemmed	Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
title_sort	variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a11076592094e3cb0288191eda7fc46
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Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer

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