Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling

BRAF inhibitors are used to treat late-stage melanoma patients harbouring BRAF mutations. Here the authors track the responses of single melanoma cells to BRAF inhibitors and show that a subset of cells rapidly escapes drug via non-genetic mechanisms and incurs DNA damage.

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Autores principales:	Chen Yang, Chengzhe Tian, Timothy E. Hoffman, Nicole K. Jacobsen, Sabrina L. Spencer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a13f959447645ecb054fba975625421
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spelling	oai:doaj.org-article:6a13f959447645ecb054fba9756254212021-12-02T17:03:35ZMelanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling10.1038/s41467-021-21549-x2041-1723https://doaj.org/article/6a13f959447645ecb054fba9756254212021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21549-xhttps://doaj.org/toc/2041-1723BRAF inhibitors are used to treat late-stage melanoma patients harbouring BRAF mutations. Here the authors track the responses of single melanoma cells to BRAF inhibitors and show that a subset of cells rapidly escapes drug via non-genetic mechanisms and incurs DNA damage.Chen YangChengzhe TianTimothy E. HoffmanNicole K. JacobsenSabrina L. SpencerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Yang Chengzhe Tian Timothy E. Hoffman Nicole K. Jacobsen Sabrina L. Spencer Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
description	BRAF inhibitors are used to treat late-stage melanoma patients harbouring BRAF mutations. Here the authors track the responses of single melanoma cells to BRAF inhibitors and show that a subset of cells rapidly escapes drug via non-genetic mechanisms and incurs DNA damage.
format	article
author	Chen Yang Chengzhe Tian Timothy E. Hoffman Nicole K. Jacobsen Sabrina L. Spencer
author_facet	Chen Yang Chengzhe Tian Timothy E. Hoffman Nicole K. Jacobsen Sabrina L. Spencer
author_sort	Chen Yang
title	Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
title_short	Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
title_full	Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
title_fullStr	Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
title_full_unstemmed	Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
title_sort	melanoma subpopulations that rapidly escape mapk pathway inhibition incur dna damage and rely on stress signalling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a13f959447645ecb054fba975625421
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Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling

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