Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.

<h4>Purpose</h4>To evaluate the incidence and risk factors of neovascularization in unaffected fellow eyes of patients diagnosed with type 3 neovascularization in Korea.<h4>Methods</h4>This retrospective study included 93 unaffected fellow eyes of 93 patients diagnosed with t...

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Autores principales:	Jae Hyuck Kwak, Woo Kyung Park, Rae Young Kim, Mirinae Kim, Young-Gun Park, Young-Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a14df08238349109c2fc32c1645f646
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spelling	oai:doaj.org-article:6a14df08238349109c2fc32c1645f6462021-12-02T20:06:51ZUnaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.1932-620310.1371/journal.pone.0254186https://doaj.org/article/6a14df08238349109c2fc32c1645f6462021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254186https://doaj.org/toc/1932-6203<h4>Purpose</h4>To evaluate the incidence and risk factors of neovascularization in unaffected fellow eyes of patients diagnosed with type 3 neovascularization in Korea.<h4>Methods</h4>This retrospective study included 93 unaffected fellow eyes of 93 patients diagnosed with type 3 neovascularization. For initial type 3 neovascularization diagnosis, optical coherence tomography and angiography were conducted. These baseline data were compared between patients with and without neovascularization in their fellow eyes during the follow-up period.<h4>Results</h4>The mean follow-up period was 66.1±31.1 months. Neovascularization developed in 49 (52.8%) fellow eyes after a mean period of 29.5±19.6 months. In the fellow eye neovascularization group, the incidence of soft drusen and reticular pseudodrusen was significantly higher than that in the non-neovascularization group (83.7% vs. 36.5%, p<0.001; 67.3% vs. 40.9%, p = 0.017, respectively), but the choroidal vascularity index (CVI) showed a significantly lower value (60.7±2.0% vs. 61.7±2.5%; p = 0.047). The presence of reticular pseudodrusen was related with the duration from baseline to development of fellow eye neovascularization (p = 0.038).<h4>Conclusion</h4>Neovascularization developed in 52.8% of unaffected fellow eyes. The presence of soft drusen, reticular pseudodrusen, and lower CVI values can be considered risk factors of neovascularization in unaffected fellow eyes of patients with type 3 neovascularization. The lower CVI values suggest that choroidal ischemic change may affect the development of choroidal neovascularization in these patients.Jae Hyuck KwakWoo Kyung ParkRae Young KimMirinae KimYoung-Gun ParkYoung-Hoon ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254186 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Hyuck Kwak Woo Kyung Park Rae Young Kim Mirinae Kim Young-Gun Park Young-Hoon Park Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
description	<h4>Purpose</h4>To evaluate the incidence and risk factors of neovascularization in unaffected fellow eyes of patients diagnosed with type 3 neovascularization in Korea.<h4>Methods</h4>This retrospective study included 93 unaffected fellow eyes of 93 patients diagnosed with type 3 neovascularization. For initial type 3 neovascularization diagnosis, optical coherence tomography and angiography were conducted. These baseline data were compared between patients with and without neovascularization in their fellow eyes during the follow-up period.<h4>Results</h4>The mean follow-up period was 66.1±31.1 months. Neovascularization developed in 49 (52.8%) fellow eyes after a mean period of 29.5±19.6 months. In the fellow eye neovascularization group, the incidence of soft drusen and reticular pseudodrusen was significantly higher than that in the non-neovascularization group (83.7% vs. 36.5%, p<0.001; 67.3% vs. 40.9%, p = 0.017, respectively), but the choroidal vascularity index (CVI) showed a significantly lower value (60.7±2.0% vs. 61.7±2.5%; p = 0.047). The presence of reticular pseudodrusen was related with the duration from baseline to development of fellow eye neovascularization (p = 0.038).<h4>Conclusion</h4>Neovascularization developed in 52.8% of unaffected fellow eyes. The presence of soft drusen, reticular pseudodrusen, and lower CVI values can be considered risk factors of neovascularization in unaffected fellow eyes of patients with type 3 neovascularization. The lower CVI values suggest that choroidal ischemic change may affect the development of choroidal neovascularization in these patients.
format	article
author	Jae Hyuck Kwak Woo Kyung Park Rae Young Kim Mirinae Kim Young-Gun Park Young-Hoon Park
author_facet	Jae Hyuck Kwak Woo Kyung Park Rae Young Kim Mirinae Kim Young-Gun Park Young-Hoon Park
author_sort	Jae Hyuck Kwak
title	Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
title_short	Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
title_full	Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
title_fullStr	Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
title_full_unstemmed	Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.
title_sort	unaffected fellow eye neovascularization in patients with type 3 neovascularization: incidence and risk factors.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6a14df08238349109c2fc32c1645f646
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Unaffected fellow eye neovascularization in patients with type 3 neovascularization: Incidence and risk factors.

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