TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn

The potential role of TET proteins in adult neurogenesis is unknown. In this study, authors show that TET3 is essentially required for the maintenance of the NSC pool in the adult subventricular zone niche by preventing premature differentiation of NSCs, via direct binding and repression of the pate...

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Autores principales:	Raquel Montalbán-Loro, Anna Lozano-Ureña, Mitsuteru Ito, Christel Krueger, Wolf Reik, Anne C. Ferguson-Smith, Sacri R. Ferrón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a16a9a8341a4206bf85aaf5f9a6ae31
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spelling	oai:doaj.org-article:6a16a9a8341a4206bf85aaf5f9a6ae312021-12-02T15:35:11ZTET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn10.1038/s41467-019-09665-12041-1723https://doaj.org/article/6a16a9a8341a4206bf85aaf5f9a6ae312019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09665-1https://doaj.org/toc/2041-1723The potential role of TET proteins in adult neurogenesis is unknown. In this study, authors show that TET3 is essentially required for the maintenance of the NSC pool in the adult subventricular zone niche by preventing premature differentiation of NSCs, via direct binding and repression of the paternal transcribed allele of the imprinted gene SnrpnRaquel Montalbán-LoroAnna Lozano-UreñaMitsuteru ItoChristel KruegerWolf ReikAnne C. Ferguson-SmithSacri R. FerrónNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raquel Montalbán-Loro Anna Lozano-Ureña Mitsuteru Ito Christel Krueger Wolf Reik Anne C. Ferguson-Smith Sacri R. Ferrón TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
description	The potential role of TET proteins in adult neurogenesis is unknown. In this study, authors show that TET3 is essentially required for the maintenance of the NSC pool in the adult subventricular zone niche by preventing premature differentiation of NSCs, via direct binding and repression of the paternal transcribed allele of the imprinted gene Snrpn
format	article
author	Raquel Montalbán-Loro Anna Lozano-Ureña Mitsuteru Ito Christel Krueger Wolf Reik Anne C. Ferguson-Smith Sacri R. Ferrón
author_facet	Raquel Montalbán-Loro Anna Lozano-Ureña Mitsuteru Ito Christel Krueger Wolf Reik Anne C. Ferguson-Smith Sacri R. Ferrón
author_sort	Raquel Montalbán-Loro
title	TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
title_short	TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
title_full	TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
title_fullStr	TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
title_full_unstemmed	TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn
title_sort	tet3 prevents terminal differentiation of adult nscs by a non-catalytic action at snrpn
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6a16a9a8341a4206bf85aaf5f9a6ae31
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TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn

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