Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation within active replication forks locally perturb repli...

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Autores principales:	Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, Eli Rothenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a1841de8fd7414d95ee7b037e0668ec
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spelling	oai:doaj.org-article:6a1841de8fd7414d95ee7b037e0668ec2021-12-02T15:37:56ZSingle-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling10.1038/s41467-021-22830-92041-1723https://doaj.org/article/6a1841de8fd7414d95ee7b037e0668ec2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22830-9https://doaj.org/toc/2041-1723In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation within active replication forks locally perturb replisome dynamics and damage response signaling, which require RPA and FANCJ for regulation.Wei Ting C. LeeYandong YinMichael J. MortenPeter TonziPam Pam GwoDiana C. OdermattMauro ModestiSharon B. CantorKerstin GariTony T. HuangEli RothenbergNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Ting C. Lee Yandong Yin Michael J. Morten Peter Tonzi Pam Pam Gwo Diana C. Odermatt Mauro Modesti Sharon B. Cantor Kerstin Gari Tony T. Huang Eli Rothenberg Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
description	In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation within active replication forks locally perturb replisome dynamics and damage response signaling, which require RPA and FANCJ for regulation.
format	article
author	Wei Ting C. Lee Yandong Yin Michael J. Morten Peter Tonzi Pam Pam Gwo Diana C. Odermatt Mauro Modesti Sharon B. Cantor Kerstin Gari Tony T. Huang Eli Rothenberg
author_facet	Wei Ting C. Lee Yandong Yin Michael J. Morten Peter Tonzi Pam Pam Gwo Diana C. Odermatt Mauro Modesti Sharon B. Cantor Kerstin Gari Tony T. Huang Eli Rothenberg
author_sort	Wei Ting C. Lee
title	Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
title_short	Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
title_full	Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
title_fullStr	Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
title_full_unstemmed	Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
title_sort	single-molecule imaging reveals replication fork coupled formation of g-quadruplex structures hinders local replication stress signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a1841de8fd7414d95ee7b037e0668ec
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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

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