Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation within active replication forks locally perturb repli...
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Autores principales: | Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, Eli Rothenberg |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/6a1841de8fd7414d95ee7b037e0668ec |
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