ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

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Detalles Bibliográficos
Autores principales: Yu Zhang, Xian Guo, Wanyao Yan, Yan Chen, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Weili Xue, Qiaoqiao Zhou, Ling Zheng, Shun Wang, Bin Wu, Xinran Liu, Liang Ma, Lianqi Huang, Kun Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf
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Descripción
Sumario:NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

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