ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

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Autores principales:	Yu Zhang, Xian Guo, Wanyao Yan, Yan Chen, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Weili Xue, Qiaoqiao Zhou, Ling Zheng, Shun Wang, Bin Wu, Xinran Liu, Liang Ma, Lianqi Huang, Kun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf
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spelling	oai:doaj.org-article:6a192f712a044e0886bb7d51ea109eaf2021-12-02T15:38:52ZANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ10.1038/s41467-017-02355-w2041-1723https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02355-whttps://doaj.org/toc/2041-1723NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.Yu ZhangXian GuoWanyao YanYan ChenMengxiang KeCheng ChengXiuqin ZhuWeili XueQiaoqiao ZhouLing ZhengShun WangBin WuXinran LiuLiang MaLianqi HuangKun HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Zhang Xian Guo Wanyao Yan Yan Chen Mengxiang Ke Cheng Cheng Xiuqin Zhu Weili Xue Qiaoqiao Zhou Ling Zheng Shun Wang Bin Wu Xinran Liu Liang Ma Lianqi Huang Kun Huang ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
description	NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.
format	article
author	Yu Zhang Xian Guo Wanyao Yan Yan Chen Mengxiang Ke Cheng Cheng Xiuqin Zhu Weili Xue Qiaoqiao Zhou Ling Zheng Shun Wang Bin Wu Xinran Liu Liang Ma Lianqi Huang Kun Huang
author_facet	Yu Zhang Xian Guo Wanyao Yan Yan Chen Mengxiang Ke Cheng Cheng Xiuqin Zhu Weili Xue Qiaoqiao Zhou Ling Zheng Shun Wang Bin Wu Xinran Liu Liang Ma Lianqi Huang Kun Huang
author_sort	Yu Zhang
title	ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
title_short	ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
title_full	ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
title_fullStr	ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
title_full_unstemmed	ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
title_sort	angptl8 negatively regulates nf-κb activation by facilitating selective autophagic degradation of ikkγ
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf
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ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

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