ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

Saved in:
Bibliographic Details
Main Authors: Yu Zhang, Xian Guo, Wanyao Yan, Yan Chen, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Weili Xue, Qiaoqiao Zhou, Ling Zheng, Shun Wang, Bin Wu, Xinran Liu, Liang Ma, Lianqi Huang, Kun Huang
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/6a192f712a044e0886bb7d51ea109eaf

Similar Items