Mendelian randomization study of interleukin (IL)-1 family and lung cancer

Abstract The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding. We appraised the association of IL-1 family members/receptors with lung cancer and its subtypes [lung adenocarcinoma (LUAD) and squamou...

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Autores principales:	Zhao Yang, C. Mary Schooling, Man Ki Kwok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a230508876e4b669955f93eca42a582
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spelling	oai:doaj.org-article:6a230508876e4b669955f93eca42a5822021-12-02T17:51:12ZMendelian randomization study of interleukin (IL)-1 family and lung cancer10.1038/s41598-021-97099-52045-2322https://doaj.org/article/6a230508876e4b669955f93eca42a5822021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97099-5https://doaj.org/toc/2045-2322Abstract The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding. We appraised the association of IL-1 family members/receptors with lung cancer and its subtypes [lung adenocarcinoma (LUAD) and squamous cell lung cancer (LUSC)] using two-sample Mendelian randomization. This study found that no IL-1 family members/receptors were significantly associated with lung cancer and its subtypes risk after correction for multiple testing. However, suggestive total effects of increased risk were noted for genetically predicted IL-1Racp with lung cancer (P = 0.006), IL-1α with LUAD (P = 0.027), and IL-1Racp with LUSC (P = 0.008). Suggestive direct effects were also noted for IL-1β, IL-1Ra, IL-36γ with lung cancer, IL-1α/β, IL-1Ra with LUAD, and IL-1β, IL-18BP with LUSC, after adjusting for genetically predicted effects of other IL-1 family members/receptors. Taken together, our findings suggest that interventions decreasing IL-1Racp might protect against lung cancer, perhaps via IL-1α/β or IL-1Ra.Zhao YangC. Mary SchoolingMan Ki KwokNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhao Yang C. Mary Schooling Man Ki Kwok Mendelian randomization study of interleukin (IL)-1 family and lung cancer
description	Abstract The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding. We appraised the association of IL-1 family members/receptors with lung cancer and its subtypes [lung adenocarcinoma (LUAD) and squamous cell lung cancer (LUSC)] using two-sample Mendelian randomization. This study found that no IL-1 family members/receptors were significantly associated with lung cancer and its subtypes risk after correction for multiple testing. However, suggestive total effects of increased risk were noted for genetically predicted IL-1Racp with lung cancer (P = 0.006), IL-1α with LUAD (P = 0.027), and IL-1Racp with LUSC (P = 0.008). Suggestive direct effects were also noted for IL-1β, IL-1Ra, IL-36γ with lung cancer, IL-1α/β, IL-1Ra with LUAD, and IL-1β, IL-18BP with LUSC, after adjusting for genetically predicted effects of other IL-1 family members/receptors. Taken together, our findings suggest that interventions decreasing IL-1Racp might protect against lung cancer, perhaps via IL-1α/β or IL-1Ra.
format	article
author	Zhao Yang C. Mary Schooling Man Ki Kwok
author_facet	Zhao Yang C. Mary Schooling Man Ki Kwok
author_sort	Zhao Yang
title	Mendelian randomization study of interleukin (IL)-1 family and lung cancer
title_short	Mendelian randomization study of interleukin (IL)-1 family and lung cancer
title_full	Mendelian randomization study of interleukin (IL)-1 family and lung cancer
title_fullStr	Mendelian randomization study of interleukin (IL)-1 family and lung cancer
title_full_unstemmed	Mendelian randomization study of interleukin (IL)-1 family and lung cancer
title_sort	mendelian randomization study of interleukin (il)-1 family and lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a230508876e4b669955f93eca42a582
work_keys_str_mv	AT zhaoyang mendelianrandomizationstudyofinterleukinil1familyandlungcancer AT cmaryschooling mendelianrandomizationstudyofinterleukinil1familyandlungcancer AT mankikwok mendelianrandomizationstudyofinterleukinil1familyandlungcancer
_version_	1718379289844383744

Mendelian randomization study of interleukin (IL)-1 family and lung cancer

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