A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma

Abstract Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported that ferroptosis is associated with the prognosis of OV patients. However, the mechanism by which this occurs is not well understood. We utilized Genotype-Tissue Expression (GTEx) and The Cancer Genome...

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Autores principales:	Zhixiang Yu, Haiyan He, Yanan Chen, Qiuhe Ji, Min Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a2b6a1df1764df0a90323aa51352486
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spelling	oai:doaj.org-article:6a2b6a1df1764df0a90323aa513524862021-12-02T15:02:23ZA novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma10.1038/s41598-021-90126-52045-2322https://doaj.org/article/6a2b6a1df1764df0a90323aa513524862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90126-5https://doaj.org/toc/2045-2322Abstract Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported that ferroptosis is associated with the prognosis of OV patients. However, the mechanism by which this occurs is not well understood. We utilized Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) to identify ferroptosis-related genes in OV. In the present study, we applied Cox regression analysis to select hub genes and used the least absolute shrinkage and selection operator to construct a prognosis prediction model with mRNA expression profiles and clinical data from TCGA. A series of analyses for this signature was performed in TCGA. We then verified the identified signature using International Cancer Genome Consortium (ICGC) data. After a series of analyses, we identified six hub genes (DNAJB6, RB1, VIMP/ SELENOS, STEAP3, BACH1, and ALOX12) that were then used to construct a model using a training data set. The model was then tested using a validation data set and was found to have high sensitivity and specificity. The identified ferroptosis-related hub genes might play a critical role in the mechanism of OV development. The gene signature we identified may be useful for future clinical applications.Zhixiang YuHaiyan HeYanan ChenQiuhe JiMin SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhixiang Yu Haiyan He Yanan Chen Qiuhe Ji Min Sun A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
description	Abstract Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported that ferroptosis is associated with the prognosis of OV patients. However, the mechanism by which this occurs is not well understood. We utilized Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) to identify ferroptosis-related genes in OV. In the present study, we applied Cox regression analysis to select hub genes and used the least absolute shrinkage and selection operator to construct a prognosis prediction model with mRNA expression profiles and clinical data from TCGA. A series of analyses for this signature was performed in TCGA. We then verified the identified signature using International Cancer Genome Consortium (ICGC) data. After a series of analyses, we identified six hub genes (DNAJB6, RB1, VIMP/ SELENOS, STEAP3, BACH1, and ALOX12) that were then used to construct a model using a training data set. The model was then tested using a validation data set and was found to have high sensitivity and specificity. The identified ferroptosis-related hub genes might play a critical role in the mechanism of OV development. The gene signature we identified may be useful for future clinical applications.
format	article
author	Zhixiang Yu Haiyan He Yanan Chen Qiuhe Ji Min Sun
author_facet	Zhixiang Yu Haiyan He Yanan Chen Qiuhe Ji Min Sun
author_sort	Zhixiang Yu
title	A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
title_short	A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
title_full	A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
title_fullStr	A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
title_full_unstemmed	A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
title_sort	novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a2b6a1df1764df0a90323aa51352486
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A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma

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