HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs

Maintenance of high turnover in tissues such as epidermis requires balance between proliferation and differentiation. Here the authors show that HNRNPK promotes RNA Polymerase II binding to proliferation and self-renewal genes as well as degradation of differentiation promoting mRNAs together with D...

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Autores principales:	Jingting Li, Yifang Chen, Xiaojun Xu, Jackson Jones, Manisha Tiwari, Ji Ling, Ying Wang, Olivier Harismendy, George L. Sen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a2cd14458fd45688f3e8283c23e0525
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spelling	oai:doaj.org-article:6a2cd14458fd45688f3e8283c23e05252021-12-02T16:58:24ZHNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs10.1038/s41467-019-12238-x2041-1723https://doaj.org/article/6a2cd14458fd45688f3e8283c23e05252019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12238-xhttps://doaj.org/toc/2041-1723Maintenance of high turnover in tissues such as epidermis requires balance between proliferation and differentiation. Here the authors show that HNRNPK promotes RNA Polymerase II binding to proliferation and self-renewal genes as well as degradation of differentiation promoting mRNAs together with DDX6 in epidermis.Jingting LiYifang ChenXiaojun XuJackson JonesManisha TiwariJi LingYing WangOlivier HarismendyGeorge L. SenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingting Li Yifang Chen Xiaojun Xu Jackson Jones Manisha Tiwari Ji Ling Ying Wang Olivier Harismendy George L. Sen HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
description	Maintenance of high turnover in tissues such as epidermis requires balance between proliferation and differentiation. Here the authors show that HNRNPK promotes RNA Polymerase II binding to proliferation and self-renewal genes as well as degradation of differentiation promoting mRNAs together with DDX6 in epidermis.
format	article
author	Jingting Li Yifang Chen Xiaojun Xu Jackson Jones Manisha Tiwari Ji Ling Ying Wang Olivier Harismendy George L. Sen
author_facet	Jingting Li Yifang Chen Xiaojun Xu Jackson Jones Manisha Tiwari Ji Ling Ying Wang Olivier Harismendy George L. Sen
author_sort	Jingting Li
title	HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
title_short	HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
title_full	HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
title_fullStr	HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
title_full_unstemmed	HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs
title_sort	hnrnpk maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mrnas
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6a2cd14458fd45688f3e8283c23e0525
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HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs

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