Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
Kynurenine-3-monooxygenase (KMO) is an emerging clinical target for treatment of neurodegenerative diseases and acute pancreatitis. Here, the authors report potent inhibitors that bind KMO in an unexpected conformation, offering structural and mechanistic insights for future drug discovery ventures.
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2017
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oai:doaj.org-article:6a2d1e05cbf54050aa6e26f4834e4b9a2021-12-02T15:38:42ZStructural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase10.1038/ncomms158272041-1723https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15827https://doaj.org/toc/2041-1723Kynurenine-3-monooxygenase (KMO) is an emerging clinical target for treatment of neurodegenerative diseases and acute pancreatitis. Here, the authors report potent inhibitors that bind KMO in an unexpected conformation, offering structural and mechanistic insights for future drug discovery ventures.Jonathan P. HutchinsonPaul RowlandMark R. D. TaylorErica M. ChristodoulouCarl HaslamClare I. HobbsDuncan S. HolmesPaul HomesJohn LiddleDamian J. MoleIain UingsAnn L. WalkerScott P. WebsterChristopher G. MowatChun-wa ChungNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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Science Q |
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Science Q Jonathan P. Hutchinson Paul Rowland Mark R. D. Taylor Erica M. Christodoulou Carl Haslam Clare I. Hobbs Duncan S. Holmes Paul Homes John Liddle Damian J. Mole Iain Uings Ann L. Walker Scott P. Webster Christopher G. Mowat Chun-wa Chung Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| description |
Kynurenine-3-monooxygenase (KMO) is an emerging clinical target for treatment of neurodegenerative diseases and acute pancreatitis. Here, the authors report potent inhibitors that bind KMO in an unexpected conformation, offering structural and mechanistic insights for future drug discovery ventures. |
| format |
article |
| author |
Jonathan P. Hutchinson Paul Rowland Mark R. D. Taylor Erica M. Christodoulou Carl Haslam Clare I. Hobbs Duncan S. Holmes Paul Homes John Liddle Damian J. Mole Iain Uings Ann L. Walker Scott P. Webster Christopher G. Mowat Chun-wa Chung |
| author_facet |
Jonathan P. Hutchinson Paul Rowland Mark R. D. Taylor Erica M. Christodoulou Carl Haslam Clare I. Hobbs Duncan S. Holmes Paul Homes John Liddle Damian J. Mole Iain Uings Ann L. Walker Scott P. Webster Christopher G. Mowat Chun-wa Chung |
| author_sort |
Jonathan P. Hutchinson |
| title |
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| title_short |
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| title_full |
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| title_fullStr |
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| title_full_unstemmed |
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| title_sort |
structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a |
| work_keys_str_mv |
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| _version_ |
1718386116765155328 |